Direct Lineage Reprogramming in the CNS
Direct Lineage Reprogramming in the CNS
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DOI：
10.1007/5584_2019_374
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Faiz, Maryam
中科院分区：
文献类型：
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作者：
Bajohr, Justine;Faiz, Maryam
直接谱系重编程是将一种特化细胞类型转化为另一种特化细胞类型，而不需要多能中间体。到目前为止，已经成功地产生了各种各样的细胞类型使用直接重编程，在体外和体内。这些新转化的细胞有可能取代因疾病和/或损伤而丢失的细胞。在这一章中，我们将集中讨论中枢神经系统中的直接重编程。我们将回顾目前在该领域的进展，关于所有主要的神经细胞类型，并探讨如何细胞异质性，无论是在启动细胞和靶细胞群体，可能会影响直接重编程。最后，我们将讨论新技术，这将提高我们对重编程过程的理解，并有助于开发更具体和更有效的未来基于CNS的重编程策略。
Direct lineage reprogramming is the conversion of one specialized cell type to another without the need for a pluripotent intermediate. To date, a wide variety of cell types have been successfully generated using direct reprogramming, both in vitro and in vivo. These newly converted cells have the potential to replace cells that are lost to disease and/or injury. In this chapter, we will focus on direct reprogramming in the central nervous system. We will review current progress in the field with regards to all the major neural cell types and explore how cellular heterogeneity, both in the starter cell and target cell population, may have implications for direct reprogramming. Finally, we will discuss new technologies that will improve our understanding of the reprogramming process and aid the development of more specific and efficient future CNS-based reprogramming strategies.