Infant Feeding, Gut Permeability, and Gut Inflammation Markers.
Infant Feeding, Gut Permeability, and Gut Inflammation Markers.
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婴儿喂养、肠道通透性和肠道炎症标志物。
DOI：
10.1097/mpg.0000000000003756
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发表时间：
2023
影响因子：
2.9
通讯作者：
Knip,Mik
中科院分区：
文献类型：
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作者：
Koivusaari,Katariina;Niinistö,Sari;Nevalainen,Jaakko;Honkanen,Jarno;Ruohtula,Terhi;Koreasalo,Mirva;Ahonen,Suvi;Åkerlund,Mari;Tapanainen,Heli;Siljander,Heli;Miettinen,MaijaE;Alatossava,Tapani;Ilonen,Jorma;Vaarala,Outi;Knip,Mik
目的肠道通透性增加和肠道炎症与1型糖尿病的发生有关。关于不同食物的摄入是否以及如何与婴儿期的这些机制联系起来，人们知之甚少。我们调查了母乳量和其他食物的摄入量是否与肠道炎症标志物浓度和通透性有关。在3、6、9和12个月大时，通过结构化问卷和3天称重食物记录评估他们的饮食。采用乳果糖/甘露醇试验评估肠道通透性，并分析3、6、9和12月龄粪便样本中的粪便钙卫蛋白和人β-防御素-2（HBD-2）浓度。食物和肠道炎症标志物浓度和渗透性之间的关联进行了分析，使用广义估计equations.ResultsGut渗透性和肠道炎症标志物浓度下降，在第一年的生活。摄入水解婴儿配方奶粉（P= 0.003）和摄入水果和果汁（P= 0.001）与较低的肠道通透性相关。水果和果汁（P< 0.001）、蔬菜（P< 0.001）和燕麦（P= 0.003）的摄入量与HBD-2浓度较低相关。较高的母乳摄入量与较高的粪便钙卫蛋白浓度相关（P< 0.001），而水果和果汁的摄入量（P< 0.001），蔬菜（P< 0.001），土豆（P= 0.007）与较低的钙卫蛋白浓度相关。结论母乳摄入量增加可能有助于钙卫蛋白浓度升高，而几种辅食可能会降低肠道通透性和婴儿肠道中钙卫蛋白和HBD-2的浓度。
ObjectivesIncreased gut permeability and gut inflammation have been linked to the development of type 1 diabetes. Little is known on whether and how intake of different foods is linked to these mechanisms in infancy. We investigated whether the amount of breast milk and intake of other foods are associated with gut inflammation marker concentrations and permeability.MethodsSeventy‐three infants were followed from birth to 12 months of age. Their diet was assessed with structured questionnaires and 3‐day weighed food records at the age of 3, 6, 9, and 12 months. Gut permeability was assessed with the lactulose/mannitol test and fecal calprotectin and human β‐defensin‐2 (HBD‐2) concentrations were analyzed from stool samples at the age of 3, 6, 9, and 12 months. The associations between foods and gut inflammation marker concentrations and permeability were analyzed using generalized estimating equations.ResultsGut permeability and gut inflammation marker concentrations decreased during the first year of life. Intake of hydrolyzed infant formula (P= 0.003) and intake of fruits and juices (P= 0.001) were associated with lower intestinal permeability. Intake of fruits and juices (P< 0.001), vegetables (P< 0.001), and oats (P= 0.003) were associated with lower concentrations of HBD‐2. Higher intake of breast milk was associated with higher fecal calprotectin concentrations (P< 0.001), while intake of fruits and juices (P< 0.001), vegetables (P< 0.001), and potatoes (P= 0.007) were associated with lower calprotectin concentrations.ConclusionsHigher intake of breast milk may contribute to higher calprotectin concentration, whereas several complementary foods may decrease gut permeability and concentrations of calprotectin and HBD‐2 in infant gut.