Progression of HIV infection in the post-HAART era among a cohort of HIV+ Greek haemophilia patients.
Progression of HIV infection in the post-HAART era among a cohort of HIV+ Greek haemophilia patients.
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后 HAART 时代一群 HIV 希腊血友病患者中 HIV 感染的进展。
DOI：
10.1111/j.1365-2516.2005.01109.x
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Karafoulidou,A
中科院分区：
文献类型：
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作者：
Katsarou,O;Touloumi,G;Antoniou,A;Kouramba,A;Hatzakis,A;Karafoulidou,A
AimThe study aims to describe the course of HIV-1 infection in the pre-and post-HAART period in a cohort of HIV+ haemophilia patients followed up up up to 21 years.MethodsThe cohort includes 158 haemophilic men with known seroconversion dates followed prospectively for a median time for 12 and 5.7 years in the pre-HAART period（1980-96）and post-HAART period（1997-2003），eithwer.ResultsThe risk of developing AIDS was lowered by 56% in the post-as followed in the pre-HAART period. 在158例患者中，69例在HAART治疗前发展为AIDS，而在1997年1月1日仍存活且无AIDS的59例受试者中，6例发展为AIDS。PCP（12.0例/1000人-年）和NHL（5.4例/1000人-年）的发生率是HAART前时代艾滋病诊断的最常见原因，在HAART后时代显着降低（两种发生率均为2.8例/1000人-年）。相反，非艾滋病死亡的相应风险在HAART后时期增加了四倍。在两个阶段的38例非艾滋病相关死亡中，13例发生在HAART后。两个阶段非AIDS死亡的主要原因是终末期肝病（ESLD）（HAART前7例，HAART后4例）。非艾滋病相关癌症的发病率也增加了在后HAART period.ConclusionIn这个血友病队列的艾滋病的风险大大降低后HAART期间，但非艾滋病死亡率有增加的趋势。在血友病受试者中，由于HCV/HIV合并感染率较高，ESLD（非AIDS死亡的主要原因）将成为日益重要的临床问题。
AimThe study aims to describe the course of HIV‐1 infection in the pre‐ and post‐HAART period in a cohort of HIV+ haemophilia patients followed up for up to 21 years.MethodsThe cohort includes 158 haemophilic men with known seroconversion dates followed up prospectively for a median time of 12 and 5.7 years in the pre‐ (1980–96) and post‐HAART period (1997–2003), respectively.ResultsThe risk of developing AIDS was lowered by 56% in the post‐ as compared to the pre‐HAART period. Of the 158 patients 69 developed AIDS in the pre‐HAART period while of the 59 subjects still alive and AIDS free on 1/1/1997 six developed AIDS. The rate of PCP (12.0 cases per 1000 person‐years) and NHL (5.4 cases per 1000 person‐years), the most common causes of AIDS diagnosis in the pre‐HAART era, were remarkably reduced in the post‐HAART era (both rates: 2.8 cases per 1000 person‐years). On the contrary, the corresponding risk for non‐AIDS deaths was fourfold increased in the post‐HAART period. Of the 38 non‐AIDS related deaths in both periods, 13 occurred post‐HAART. The predominant cause of non‐AIDS mortality in both periods was end‐stage liver disease (ESLD) (7 pre‐ and 4 post‐HAART). The rate of non‐AIDS related cancers was also increased during the post‐HAART period.ConclusionIn this haemophilia cohort the risk of AIDS has substantially reduced in the post‐HAART period, but the rate of non‐AIDS mortality tended to increase. Among haemophilia subjects, due to the high rates of HCV/HIV coinfection, ESLD, the predominant cause of non‐AIDS mortality, will become an increasingly important clinical problem.