Impact of Fundamental Diseases on Patients With COVID-19
Impact of Fundamental Diseases on Patients With COVID-19
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DOI：
10.1017/dmp.2020.139
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发表时间：
2020-12-01
影响因子：
2.7
通讯作者：
Pan, Jun
中科院分区：
文献类型：
--
作者：
Chen, Yiguang;Li, Tianhua;Pan, Jun
目的：2019 年 12 月，中国武汉出现了一种新型冠状病毒，称为严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）。与 SARS-CoV-2 病毒相关的 2019 年冠状病毒病（COVID-19）在中国和世界各地爆发。因此，我们打算揭示其潜在的临床和流行病学特征。 方法：在这项回顾性研究中，我们纳入了2020年1月16日至2020年2月5日中国官方媒体网络报道的50例确诊的SARS-CoV-2死亡病例。所有病例均由当地有资质的医疗卫生机构确诊。具体信息已通过官方渠道发布。根据报告内容，详细记录患者的性别、年龄、首发症状日期、死亡日期、主要症状、慢性基础疾病等资料，并进行分析讨论。结果：共报告死亡病例50例，中位年龄70岁，男性死亡可能性是女性的2.33倍。从首次出现症状到死亡的中位天数为 13 天，65 岁及以上人群的时间长度往往比 65 岁以下人群更短（12 天 vs 17 天；P = 0.046）。因此，老年患者从首次出现症状到死亡的天数较少（r = -0.40；P = 0.012）。结论：在我们的研究中，我们发现大多数死亡病例是患有慢性基础疾病的老年男性，他们的COVID-19进展到死亡的时间较短。同时，我们证明老年男性更容易感染COVID-19，并且死亡风险与年龄呈正相关。
Objectives:In December 2019, a new type of coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared in Wuhan, China. Serious outbreaks of coronavirus disease 2019 (COVID-19), related to the SARS-CoV-2 virus, have occurred throughout China and the world. Therefore, we intend to shed light on its potential clinical and epidemiological characteristics.Methods:In this retrospective study, we included 50 confirmed fatal cases of SARS-CoV-2 reported on Chinese official media networks from January 16, 2020, to February 5, 2020. All the cases were confirmed by local qualified medical and health institutions. Specific information has been released through official channels. According to the contents of the reports, we recorded in detail the gender, age, first symptom date, death date, primary symptoms, chronic fundamental diseases, and other data of the patients, and carried out analyses and discussion.Results:In total, 50 fatal cases were reported: median age was 70 y old, and males were 2.33 times more likely to die than females. The median number of days from the first symptom to death was 13, and that length of time tended to be shorter among people aged 65 and older compared with those younger than 65 (12 days vs 17 days; P = 0.046). Therefore, the older patients had fewer number of days from the first symptom to death (r = -0.40; P = 0.012).Conclusions:In our study, we found that most of the deaths were elderly men with chronic fundamental diseases, and their COVID-19 progression to death time was shorter. At the same time, we demonstrated that older men are more likely to become infected with COVID-19, and the risk of death is positively correlated with age.