Pilot test of a novel food response and attention training treatment for obesity: Brain imaging data suggest actions shape valuation.
Pilot test of a novel food response and attention training treatment for obesity: Brain imaging data suggest actions shape valuation.
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DOI：
10.1016/j.brat.2017.04.007
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发表时间：
2017-07
影响因子：
4.1
通讯作者：
Lawrence NS
中科院分区：
文献类型：
--
作者：
Stice E;Yokum S;Veling H;Kemps E;Lawrence NS
对高热量食物图像的大脑奖励和注意区域反应升高，抑制区域反应减弱，已被发现可以预测未来的体重增加。这些发现表明，减少奖励和注意区域的反应，增加抑制控制区对这些食物的反应的干预可能会减少暴饮暴食。我们在社区招募的超重/肥胖成年人中进行了一项随机试点实验，以验证以下假设：与非食物图像的对照训练相比，个性化高热量和低热量食物图像的多方面食物反应和注意力训练会产生对食物图像和体脂的行为和神经反应的变化。与对照组观察到的变化相比，完成干预与高热量食物图像的奖励和注意区域反应的显著减少（Mean Cohen’s d = 1.54），学习行为证据，高热量食物的适口性评级和货币价值的降低（p = 0.009, d = 0.92）以及4周内更多的体脂减少（p = 0.009, d = 0.90）相关，尽管体脂影响在6个月的随访中并不显著。结果表明，这种多方面的反应和注意力训练干预与奖励和注意力区域对食物线索的反应降低以及体脂减少有关。由于这种内隐训练治疗既简单又便宜，而且不需要自上而下的执行控制，这是负能量平衡肥胖治疗所必需的，如果未来的研究能够确定如何创造更持久的效果，它可能在治疗肥胖方面有用。
Elevated brain reward and attention region response, and weaker inhibitory region response to high-calorie food images have been found to predict future weight gain. These findings suggest that an intervention that reduces reward and attention region response and increases inhibitory control region response to such foods might reduce overeating. We conducted a randomized pilot experiment that tested the hypothesis that a multi-faceted food response and attention training with personalized high- and low- calorie food images would produce changes in behavioral and neural responses to food images and body fat compared to a control training with non-food images among community-recruited overweight/obese adults. Compared to changes observed in controls, completing the intervention was associated with significant reductions in reward and attention region response to high-calorie food images (Mean Cohen’s d = 1.54), behavioral evidence of learning, reductions in palatability ratings and monetary valuation of high-calorie foods (p = .009, d’s = .92), and greater body fat loss over a 4-week period (p = .009, d = .90), though body fat effects were not significant by 6-month follow-up. Results suggest that this multifaceted response and attention training intervention was associated with reduced reward and attention region responsivity to food cues, and a reduction in body fat. Because this implicit training treatment is both easy and inexpensive to deliver, and does not require top-down executive control that is necessary for negative energy balance obesity treatment, it may prove useful in treating obesity if future studies can determine how to create more enduring effects.
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