Unexpected Extension of Usage of PPh3/CBr4, a Versatile Reagent: Isomerization of Aromatic Allylic Alcohols
Unexpected Extension of Usage of PPh3/CBr4, a Versatile Reagent: Isomerization of Aromatic Allylic Alcohols
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多功能试剂 PPh3/CBr4 用途的意外扩展：芳香烯丙醇的异构化
DOI：
10.1246/cl.2012.1597
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发表时间：
2012-12-05
影响因子：
1.6
通讯作者：
Li, Ying
中科院分区：
文献类型：
--
作者：
Gong, Wanchun;Liu, Yun;Li, Ying
PPh3/CBr4 催化的 2-芳香烯丙醇异构化为相应的饱和醛或酮已在室温下在温和且无金属的条件下实现了良好至优异的产率。这种新方法已成功应用于布洛芬的四步合成。
The PPh3/CBr4-catalyzed isomerization of 2-aromatic allylic alcohols into the corresponding saturated aldehydes or ketones has been achieved at room temperature in good to excellent yields under mild and metal-free conditions. This new methodology has been applied successfully to the synthesis of ibuprofen in four steps.