PLASMODIUM-FALCIPARUM MATURATION ABOLISHES PHYSIOLOGIC RED-CELL DEFORMABILITY
PLASMODIUM-FALCIPARUM MATURATION ABOLISHES PHYSIOLOGIC RED-CELL DEFORMABILITY
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DOI：
10.1126/science.6362007
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
KROGSTAD, DJ
中科院分区：
文献类型：
--
作者：
CRANSTON, HA;BOYLAN, CW;KROGSTAD, DJ
正常红细胞在通过脾脏和周围毛细血管时会明显变形。在这些研究中，通过流变仪检查了恶性疟原虫感染和成熟对体外暴露于流体剪切应力的寄生红细胞变形能力的影响。含有寄生虫早期（环）红细胞阶段的红细胞在生理剪切应力下的变形能力受损，并且恢复正常形状的速度更慢。含有更成熟寄生虫（滋养体或裂殖体）的红细胞在相同条件下没有表现出变形。这些结果提供了一种机制来解释脾脏从免疫和非免疫宿主的循环中去除寄生红细胞的能力。
Normal red cells deform markedly as they pass through the spleen and the peripheral capillaries. In these studies, the effects of P. falciparum infection and maturation on the deformability of parasitized red cells exposed to fluid shear stress in vitro were examined by means of a rheoscope. Red cells containing the early (ring) erythrocytic stage of the parasite have impaired deformability at physiologic shear stresses, and recover their normal shape more slowly. Red cells containing more mature parasites (trophozoites or schizonts) exhibit no deformation under the same conditions. These results provide a mechanism to explain the ability of the spleen to remove parasitized red cells from the circulation of both immune and nonimmune hosts.