Polyurethane from biosource as a new material for fabrication of microfluidic devices by rapid prototyping
Polyurethane from biosource as a new material for fabrication of microfluidic devices by rapid prototyping
复制标题
DOI：
10.1016/j.chroma.2007.09.081
复制
发表时间：
2007-11-30
影响因子：
4.1
通讯作者：
Carrilho, Emanuel
中科院分区：
文献类型：
--
作者：
Piccin, Evandro;Tomazelli Coltro, Wendell Karlos;Carrilho, Emanuel
本文介绍了从蓖麻油(CO)生物源中提取的弹性体聚氨酯(PU)作为一种新型材料，利用快速成型技术制造微流控器件。包括不可逆定标步骤，通过在标准光刻和电沉积的正极高浮雕模具上直接浇注PU树脂，在小于I it的情况下制备了PU微芯片。用扫描电子显微镜(SEM)和轮廓术对微通道进行了物理表征。通过接触角测量对聚合物表面进行了表征，结果表明，经氧等离子体处理后的PU表面亲水性增强。在不同pH值下，聚合物表面在pH为7时，在阴极方向产生2.6×10~(-4)cm2·V~(-1)S(-1)的电渗流。通过测定PU在24小时内的溶胀度，测试了PU与各种溶剂和电解质的相容性。通过制作微型化的毛细管电泳仪评价了使用该新材料制作的微流控系统的性能。以肾上腺素和L多巴为模型分析物，在水溶液中进行分离，并用末端通道安培法进行检测。(C)2007 Elsevier B.V.保留所有权利。
This paper presents the use of elastomeric polyurethane (PU), derived from castor oil (CO) biosource, as a new material for fabrication of microfluidic devices by rapid prototyping. Including the irreversible scaling step, PU microchips were fabricated in less than I It by casting PU resin directly on the positive high-relief molds fabricated by standard photolithography and nickel electrodeposition. Physical characterization of microchannels was performed by scanning electron microscopy (SEM) and profilometry. Polymer surface was characterized using contact angle measurements and the results showed that the hydrophilicity of the PU surface increases after oxygen plasma treatment. The polymer surface demonstrated the capability of generating an electroosmotic flow (EOF) of 2.6 x 10(-4) CM2 V-1 s(-1) at pH 7 in the cathode direction, which was characterized by current monitoring method at different pH values. The compatibility of PU with a wide range of solvents and electrolytes was tested by determining its degree of swelling over a 24 h period of contact. The performance of microfluidic systems fabricated using this new material was evaluated by fabricating miniaturized capillary electrophoresis systems. Epinephrine and L-DOPA, as model analytes, were separated in aqueous solutions and detected with end-channel amperometric detection. (c) 2007 Elsevier B.V. All rights reserved.