Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression.
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression.
复制标题
DOI：
10.1016/j.ebiom.2016.12.007
复制
发表时间：
2017-02
期刊：
影响因子：
11.1
通讯作者：
Tsubota K
中科院分区：
文献类型：
--
作者：
Torii H;Kurihara T;Seko Y;Negishi K;Ohnuma K;Inaba T;Kawashima M;Jiang X;Kondo S;Miyauchi M;Miwa Y;Katada Y;Mori K;Kato K;Tsubota K;Goto H;Oda M;Hatori M;Tsubota K
近视的患病率在全球范围内不断增加。户外活动是近视控制的重要环境因素之一。在这里，我们表明，紫光（VL，360-400 nm波长）抑制近视进展。首先，我们证实VL抑制了鸡近视模型中的眼轴长度（AL）延长。表达微阵列分析显示，近视抑制基因EGR 1上调VL曝光。在相同条件下，VL照射诱导鸡脉络膜视网膜组织中EGR 1的表达显著高于蓝光。接下来，我们进行了回顾性临床研究，比较近视儿童戴眼镜（VL封闭）和两种类型的接触镜（部分VL封闭和VL透射）之间的AL延长。数据显示VL透射接触镜最能抑制近视进展。可见，视力是影响近视控制的重要户外环境因素之一。由于过度的紫外线防护，VL容易被排除在我们的现代社会之外，VL暴露可以是预防近视进展的一种策略。紫光（360-400 nm波长）抑制了鸡近视模型和人类的眼轴长度延长。近视抑制基因EGR 1被紫光照射上调。紫光是户外环境中抑制近视的因素之一，但在现代社会中却很缺乏。近视（近视）在世界范围内一直在增加，特别是在过去的50年里。我们对小鸡和人类的研究表明，紫光（360-400 nm波长）抑制近视进展。在分子水平上，我们发现紫光增加了已知预防近视的基因EGR 1的表达。有趣的是，紫光在我们的现代社会中是缺乏的，因为各种防紫外线的产品不透射紫光，并且光源如LED不辐射紫光。紫外线防护对眼部健康很重要，但过度的紫外线防护，包括紫光，应从近视控制的角度重新考虑。
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression. Violet light (360–400 nm wavelengths) suppressed the axial length elongation both in a chick myopia model and in human. The myopia suppressive gene EGR1 was upregulated by the violet light exposure. Violet light, one of the myopia suppressive factors in the outdoor environment, is deficient from our modern society. Short-sightedness (myopia) has been increasing worldwide especially over the past 50 years. Our studies on chicks and humans revealed that violet light (360–400 nm wavelength) suppressed myopia progression. At a molecular level we found that violet light increased the expression of the gene EGR1 known to prevent myopia. Interestingly, violet light is deficient in our modern society because various ultraviolet-protected products are not transmitting violet light, and light sources such as LED irradiate no violet light. Ultraviolet protection is important for ocular health, but excessive ultraviolet protection, including violet light, should be reconsidered from the aspect of myopia control.