Effect of repeated visual traumatic stimuli on the event related P3 brain potential in post-traumatic stress disorder
Effect of repeated visual traumatic stimuli on the event related P3 brain potential in post-traumatic stress disorder
复制标题
DOI：
10.3109/00207459608986350
复制
发表时间：
1996-01-01
影响因子：
2.2
通讯作者：
Furman, V
中科院分区：
文献类型：
--
作者：
Bleich, A;Attias, J;Furman, V
创伤后应激障碍（PTSD）患者的特征在于对创伤性刺激的超敏反应，其可以表现为自动和非自愿的认知反应。电生理学上，这可以被记录为增强的视觉P3（P300）事件相关电位（ERP）。本研究探讨了P3的变化，在重复的创伤性图片刺激的视觉歧视oddball范式的形式提出了40名以色列退伍军人与创伤后应激障碍。被试被要求在目标刺激（家畜图片）出现时按下按钮，并忽略所有非目标刺激（无关的家具/花卉图片和创伤性战斗相关图片）。平均而言，与对照组相比，PTSD患者对战斗相关图片的P3反应更早，振幅约为对照组的5倍。重复呈现与战斗有关的图片刺激，导致P3波幅迅速明显降低，潜伏期延长。对于目标刺激没有观察到这种效果。这些研究结果表明，逐渐减少的注意力资源的量是必需的，并分配给重复CRP刺激的处理。这可能是与创伤刺激的认知处理相关的抑制机制激活的结果。
Post-Traumatic Stress Disorder (PTSD) patients are characterized by a hypersensitivity to traumatic stimuli which may be expressed as an automatic and involuntary cognitive response. Electrophysiologically this can be recorded as an augmented visual P3 (P300) event related potential (ERP). This study examined P3 changes in response to repeated traumatic pictorial stimuli presented in the form of a visual discrimination oddball paradigm to 40 Israeli combat veterans with and without PTSD. Subjects were asked to press a button when target stimuli (domestic animal pictures) appeared, and to ignore all non-target stimuli (irrelevant pictures of furnishings/flowers and traumatic combat related pictures). On average, P3 in response to combat related pictures was earlier and approximately 5 times greater in amplitude for the PTSD patients as compared to the controls. Repeated combat related pictures stimuli presentation resulted in a rapid and appreciable P3 amplitude reduction and latency prolongation. This effect was not observed for the target stimuli. These findings suggest that a gradually reduced amount of attentional resource is required and allocated to the processing of repeated CRP stimuli. This may occur as a consequence of the activation of an inhibitory mechanism related to the cognitive processing of traumatic stimuli.