Evaluation of a poly-l-lactic acid membrane and membrane fixing pin for guided tissue regeneration on bone defects in dogs
Evaluation of a poly-l-lactic acid membrane and membrane fixing pin for guided tissue regeneration on bone defects in dogs
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DOI：
10.1016/j.tripleo.2003.09.009
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发表时间：
2004-02-01
期刊：
影响因子：
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通讯作者：
Yamada, S
中科院分区：
文献类型：
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作者：
Amano, Y;Ota, M;Yamada, S
目标。本研究的目的是阐明聚乳酸和膜固定针结合引导骨再生治疗犬骨缺损的有效性。研究设计。8只比格犬行截骨术，造成骨缺损。第一组：用测试膜覆盖一个缺陷，用固定针固定。第二组：另一缺陷覆盖试验膜，未用固定针固定。对照组不敷膜。这些狗在治疗24或36周后被杀死。切片染色并在显微镜下评估。数据进行统计学分析。24周时未观察到试验膜的降解和再吸收，但在36周时注意到。在24周和36周后，I组缺损大部分完全闭合并新生骨，而对照组缺损仅在骨缺损底部观察到少量新生骨。36周后，试验膜和膜固定针下空间的新骨体积百分比（62.2%）大于未使用膜固定针组（53.2%），而对照组只有43.9%的缺损区域被新骨填充。本研究结果表明，聚乳酸膜和膜固定针可以通过将周围软组织从伤口区域排除来确保骨再生。
Objectives. The purpose of the study was to clarify the usefulness of a poly-l-lactic acid and membrane fixing pin, used in combination with guided bone regeneration, on bone defects in dogs.Study design. Osteotomies bone defects were created in 8 beagle dogs. Group I: one defect was covered with test membrane and held by fixing pins. Group II: the other defect was covered test membrane and not held by fixing pins. The control group received no membrane. The dogs were killed after 24 or 36 weeks of healing. Sections were stained and evaluated microscopically. Data were analyzed statistically.Results. The degradation and resorption of test membrane was not observed at 24 weeks but was noted at 36 weeks. After 24 and 36 weeks, most of Group I defects were completely closed with new bone, while in the control defects, only a small amount of new bone was observed at the bottom of the bone defects. After 36 weeks, the percentage of new bone volume (62.2%) in the space beneath the test membrane and membrane fixing pin (Group I) was greater than that without a membrane fixing pin-53.2% (Group II), whereas only 43.9% of the defect area in the control group was filled with new bone.Conclusion. The results of this study show that a poly-l-lactic acid membrane and membrane fixing pin permit bone regeneration that can be ensured by excluding surrounding soft tissues from the wound area.