New nucleoside analogues for chronic hepatitis B.
New nucleoside analogues for chronic hepatitis B.
复制标题
治疗慢性乙型肝炎的新核苷类似物。
作者：
S. Schalm;R. D. de Man;R. Heijtink;H. Niesters
In recent years, an in vitro system for screening nucleoside analogues against hepatitis B virus has yielded several compounds with a high therapeutic index. Phase I and II studies have also shown a potent in vivo antiviral effect of fialuridine and lamivudine in patients with chronic hepatitis B. The use of fialuridine was associated with unexpectedly severe mitochondrial dysfunction; in contrast, lamivudine had virtually no side-effects. Experience in liver transplant patients with recurrent hepatitis B shows that famciclovir may be another effective antivirotic drug with good tolerance.
