Parallel Amino Acid Deletions of Prestin Protein in Two Dramatically Divergent Bat Lineages Suggest the Complexity of the Evolution of Echolocation in Bats
Parallel Amino Acid Deletions of Prestin Protein in Two Dramatically Divergent Bat Lineages Suggest the Complexity of the Evolution of Echolocation in Bats
复制标题
两个截然不同的蝙蝠谱系中 prestin 蛋白的平行氨基酸缺失表明蝙蝠回声定位进化的复杂性
DOI：
10.3161/15081109acc2018.20.2.003
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发表时间：
2019-02
影响因子：
1
通讯作者：
Hua Panyu
中科院分区：
文献类型：
--
作者：
Ren Min;Sun Haijian;Bo Shunqi;Zhang Shuyi;Hua Panyu
The membrane motor protein, prestin, encoded by gene Prestin, provides the electromotility to cochlear outer hair cells (OHCs) and is therefore considered responsible for cochlea's high sensitivity to sound waves. Echolocating bats use ultrasound for orientation and hunting. In this study, we obtained the complete Prestin coding sequences of 60 mammal taxa. Alignment results detected the same 3-bp deletion mutation (c.1833_1835del in exon 18) in two bat lineages, Pteropodidae and Emballonuroidea, and caused an amino acid deletion (p.Asp611del). These two bat lineages orient with vision and echolocation, separately, suggesting that the parallel deletion occurred independently after their split. Homology modeling of the protein structures indicated contrasting structural variations after the deletion of this amino acid. Estimation of the distributions of the surface electrostatic potential coincided with the structural variation. Our findings suggest the complexity of the echolocation in bats but functionality analyses are needed to illuminate it.
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影响因子：
--
作者：
S. Rossiter;Shuyi Zhang;Yang Liu
通讯作者：
S. Rossiter;Shuyi Zhang;Yang Liu
影响因子：
1.7
作者：
Jing Zheng;Kevin B. Long;W. Shen;L. Madison;P. Dallos
通讯作者：
Jing Zheng;Kevin B. Long;W. Shen;L. Madison;P. Dallos
DOI：
10.1073/pnas.071613498
发表时间：
2001-03-27
影响因子：
11.1
作者：
Ludwig, J;Oliver, D;Fakler, B
通讯作者：
Fakler, B
DOI：
10.1111/j.1469-7793.2001.0661h.x
发表时间：
2001-03
期刊：
The Journal of Physiology
影响因子：
--
作者：
J. Santos-Sacchi;Weixing Shen;Jing Zheng;P. Dallos
通讯作者：
J. Santos-Sacchi;Weixing Shen;Jing Zheng;P. Dallos
通过分子和电生理学方法估计蝙蝠（翼手目）的弱光视觉差异。
影响因子：
4.6
作者：
Liu HQ;Wei JK;Li B;Wang MS;Wu RQ;Rizak JD;Zhong L;Wang L;Xu FQ;Shen YY;Hu XT;Zhang YP
通讯作者：
Zhang YP