Vitamin A in pregnancy:: requirements and safety limits
Vitamin A in pregnancy:: requirements and safety limits
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DOI：
10.1093/ajcn/71.5.1325s
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发表时间：
2000-05-01
影响因子：
7.1
通讯作者：
Pascal, G
中科院分区：
文献类型：
--
作者：
Azaïs-Braesco, V;Pascal, G
维生素A的大多数功能是通过视黄酸与调节基因组表达的特异性核受体的结合来介导的。最近在转基因小鼠中的实验工作清楚地表明，正常的胚胎发育取决于分化细胞中受体的正确空间和时间表达以及视黄酸的特定形式的结合。这意味着母体化合物维生素A可以以适当的形式和数量获得。维生素A的过量饮食摄入与人类的致畸性有关，
Most of the functions of vitamin A are mediated through the binding of retinoic acid to specific nuclear receptors that regulate genomic expression. Recent experimental work in transgenic mice showed clearly that normal embryonic development depends on the correct spatial and temporal expression of the receptors in the differentiating cells and on the binding of specific forms of retinoic acid. This implies that the parent compound, vitamin A, is available in adequate forms and quantities. Excessive dietary intake of vitamin A has been associated with teratogenicity in humans in