ASYMPTOMATIC HUMAN CALICIVIRUS INFECTION IN A DAY-CARE-CENTER
ASYMPTOMATIC HUMAN CALICIVIRUS INFECTION IN A DAY-CARE-CENTER
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DOI：
10.1097/00006454-199003000-00009
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发表时间：
1990-03-01
影响因子：
3.6
通讯作者：
PICKERING, LK
中科院分区：
文献类型：
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作者：
MATSON, DO;ESTES, MK;PICKERING, LK
人类杯状病毒（Human caliciviruses，HCV）是近年来发现的与胃肠炎相关的病毒。我们在一项腹泻的纵向研究中，在一个日托中心（DCC）的一个房间发生的胃肠炎爆发中发现了HCV感染。利用酶联免疫测定法和免疫吸附电镜检测HCV，我们测试了所有儿童在出席期间的疾病爆发，并在之前和之后的几周内的标本。14名儿童中记录了HCV感染，其中11名无症状。14名HCV感染儿童中有13名为8个月或更小。HCV感染的新病例发生在4周内。在调查期间，40%的1岁以下儿童感染了HCV。很少有记录的HCV感染报告。这可能与早期主要无症状感染的高发病率有关，导致4岁时HCV抗体的高流行率。
Human caliciviruses (HCVs) are little known, recently recognized viruses associated with gastroenteritis. We identified HCV infection in an outbreak of gastroenteritis which occurred in one room of a day care center (DCC) participation in a longitudinal study of diarrhea. Utilizing an enzyme-linked immunoasay and immunosorbent electron microscopy to detect HCV, we tested specimens from all children in attendance during the period of the illness outbreak and during prior and subsequent weeks. HCV infection was documented in 14 children, 11 of whom were asymptomatic. Thirteen of the 14 HCV-infected children were 8 months of age or younger. New cases of HCV infection occurred during a 4-week period. Forty percent of children less than 1 year of age were infected with HCV during the period of investigation. Few documented HCV infections have been reported. This may be related to a high attack rate of predominantly asymptomatic infections in early life, resulting in a high prevalence of antibody to HCV by 4 years of age.