Helicobacter pylori infection and inflammatory bowel disease: Is there a link?
Helicobacter pylori infection and inflammatory bowel disease: Is there a link?
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DOI：
10.3748/wjg.v20.i21.6374
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发表时间：
2014-06-07
影响因子：
4.3
通讯作者：
Mantzaris, Gerassimos J.
中科院分区：
文献类型：
--
作者：
Papamichael, Konstantinos;Konstantopoulos, Panagiotis;Mantzaris, Gerassimos J.
幽门螺杆菌（H.幽门螺杆菌）感染是人类中最广泛传播的传染病之一。它可引起慢性胃炎、消化性溃疡和胃恶性肿瘤，并与胃外疾病有关。H.幽门螺杆菌引起慢性全身炎症反应，在某些情况下，可能引发自身免疫反应，并可能涉及自身免疫疾病的发病机制。虽然炎症性肠病（IBD）的发病机制尚不清楚，但它被认为是由遗传易感个体肠道中环境因素和微生物群之间复杂的相互作用引起的。几种细菌和病毒因子与IBD的病因学有关。理论上，H。幽门螺杆菌感染可能通过诱导胃和/或肠通透性的改变或通过引起免疫紊乱导致抗原物质的吸收和通过各种免疫途径的自身免疫而参与IBD的发病机制。类似的机制也可能是IBD与其他自身免疫性疾病和/或肠外表现共存的原因。然而，流行病学数据未能支持这种关联。事实上，各种研究表明H.幽门螺杆菌感染在IBD患者中较低，表明这种感染在IBD的发展中具有保护作用。在这份报告中，我们的目的是阐明拟议的机制和混淆因素的潜在联系之间的H。pylori感染和IBD。(C)2014百世登出版集团股份有限公司All rights reserved.
Helicobacter pylori (H. pylori) infection is one of the most widely spread infectious diseases in humans. It can cause chronic gastritis, peptic ulcer disease and gastric malignancies and has been associated with extra-gastric disorders. H. pylori elicit a chronic systemic inflammatory response which, under certain conditions, may trigger autoimmune reactions and may be implicated in the pathogenesis of autoimmune diseases. Although the pathogenesis of inflammatory bowel disease (IBD) is unknown, it is thought to result from complex interactions between environmental factors and microbiota in the gut of individuals who are genetically susceptible. Several bacterial and viral agents have been implicated in the aetiology of IBD. In theory, H. pylori infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements resulting in absorption of antigenic material and autoimmunity via various immunological pathways. Similar mechanisms may also be responsible for the co-existence of IBD with other autoimmune diseases and/or extra-intestinal manifestations. However, the epidemiological data fail to support this association. In fact, various studies indicate that the prevalence of H. pylori infection is low in patients with IBD, suggesting a protective role for this infection in the development of IBD. In this report, we aim to shed light on proposed mechanisms and confounding factors underlying the potential link between H. pylori infection and IBD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.