Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study.
Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study.
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DOI：
10.1016/j.rmed.2022.106826
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发表时间：
2022-06
影响因子：
4.3
通讯作者：
Biering-Sørensen T
中科院分区：
文献类型：
--
作者：
Espersen C;Platz E;Alhakak AS;Sengeløv M;Simonsen JØ;Johansen ND;Davidovski FS;Christensen J;Bundgaard H;Hassager C;Jabbari R;Carlsen J;Kirk O;Lindholm MG;Kristiansen OP;Nielsen OW;Jeschke KN;Ulrik CS;Sivapalan P;Iversen K;Stæhr Jensen JU;Schou M;Skaarup SH;Højbjerg Lassen MC;Skaarup KG;Biering-Sørensen T
肺部超声（LUS）是诊断和监测活动性COVID-19感染患者的有用工具。然而，人们对因COVID-19住院后LUS结果的变化知之甚少。在一项针对非ICU医院病房入组的COVID-19患者的前瞻性纵向研究中，成年患者在住院期间和出院后2-3个月均接受了8区LUS和血液采样。LUS图像分析对临床变量和结局设盲。共纳入71例基线和随访时LUS可解释的患者（平均年龄64岁，61%为男性，24%为急性呼吸窘迫综合征（ARDS））。在住院期间进行初始LUS后的中位72天进行随访LUS。基线时，87%的患者在≥1个区域（例如≥3条B线、融合B线或胸膜下或肺叶实变）中有病理LUS结果，而30%的患者在随访时有病理结果（p < 0.001）。从住院到随访，B线总数和LUS评分显著降低（中位数分别为17 vs. 4，p < 0.001和4 vs. 0，p < 0.001）。在随访LUS时，所有患者中有28%在≥1个区域内有≥3条B线，而在基线住院期间的ARDS患者（n = 17）中，有47%在≥1个区域内有≥3条B线。在COVID-19幸存者中，从住院到出院后2-3个月随访，LUS结果显著改善。然而，持续性B线在随访时很常见，特别是在那些最初患有ARDS的患者中。LUS似乎是监测COVID-19肺部随时间变化的一种有前途的方法。NCT 04377035。
Lung ultrasound (LUS) is a useful tool for diagnosis and monitoring in patients with active COVID-19-infection. However, less is known about the changes in LUS findings after a hospitalization for COVID-19. In a prospective, longitudinal study in patients with COVID-19 enrolled from non-ICU hospital units, adult patients underwent 8-zone LUS and blood sampling both during the hospitalization and 2–3 months after discharge. LUS images were analyzed blinded to clinical variables and outcomes. A total of 71 patients with interpretable LUS at baseline and follow up (mean age 64 years, 61% male, 24% with acute respiratory distress syndrome (ARDS)) were included. The follow-up LUS was performed a median of 72 days after the initial LUS performed during hospitalization. At baseline, 87% had pathologic LUS findings in ≥1 zone (e.g. ≥3 B-lines, confluent B-lines or subpleural or lobar consolidation), whereas 30% had pathologic findings at follow-up (p < 0.001). The total number of B-lines and LUS score decreased significantly from hospitalization to follow-up (median 17 vs. 4, p < 0.001 and 4 vs. 0, p < 0.001, respectively). On the follow-up LUS, 28% of all patients had ≥3 B-lines in ≥1 zone, whereas in those with ARDS during the baseline hospitalization (n = 17), 47% had ≥3 B-lines in ≥1 zone. LUS findings improved significantly from hospitalization to follow-up 2–3 months after discharge in COVID-19 survivors. However, persistent B-lines were frequent at follow-up, especially among those who initially had ARDS. LUS seems to be a promising method to monitor COVID-19 lung changes over time. NCT04377035.
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影响因子：
3.8
作者：
Duclos G;Bazalguette F;Allaouchiche B;Mohammedi N;Lopez A;Gazon M;Besch G;Bouvet L;Muller L;Mathon G;Arbelot C;Boucekine M;Leone M;Zieleskiewicz L
通讯作者：
Zieleskiewicz L
影响因子：
2.3
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影响因子：
2.3
作者：
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通讯作者：
Di Sabatino, Antonio
DOI：
10.1164/rccm.201003-0369oc
发表时间：
2011-02-01
影响因子：
24.7
作者：
Bouhemad, Belaid;Brisson, Helene;Rouby, Jean-Jacques
通讯作者：
Rouby, Jean-Jacques
影响因子：
2.9
作者：
Bonadia, Nicola;Carnicelli, Annamaria;Franceschi, Francesco
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