Anti-Plasmodium vivax Duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon
Anti-Plasmodium vivax Duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon
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DOI：
10.4269/ajtmh.2005.72.675
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Carvalho, LH
中科院分区：
文献类型：
--
作者：
Ceravolo, IP;Bruña-Romero, O;Carvalho, LH
间日疟原虫达菲结合蛋白 (DBP) 在红细胞侵袭过程中具有重要的功能，并为疫苗介导的免疫提供了合理的靶点。在本研究中，我们证明DBP在巴西亚马逊地区的不同人群中具有天然免疫原性，并且DBP IgG阳性受试者的比例随着接触疟疾而增加，在亚马逊地区长期接触（> 15年）的受试者中达到峰值。这种抗体反应特征与 P. viva-V 裂殖子表面蛋白 1 (MSPI19) 观察到的抗体反应特征显着不同，后者在疟疾传播水平明显不同的地区相对一致。在一小部分患有无症状间日疟原虫感染的成人样本中，我们无法检测到针对这些间日疟原虫蛋白的抗体与无症状感染之间存在任何显着相关性。我们的研究通过证明累积暴露作为产生抗 DBP IgG 反应的决定因素而提供了额外的见解，该决定因素与宿主年龄无关。
Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. viva-V merozoite surface protein 1 (MSPI19), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response.