Novel pyridino-α-pyrone sesquiterpene type pileotin produced by a sea urchin-derived Aspergillus sp.
Novel pyridino-α-pyrone sesquiterpene type pileotin produced by a sea urchin-derived Aspergillus sp.
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DOI：
10.1016/j.tetlet.2012.05.144
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发表时间：
2012-08-08
影响因子：
1.8
通讯作者：
Numata, Atsushi
中科院分区：
文献类型：
--
作者：
Kitano, Mayumi;Yamada, Takeshi;Numata, Atsushi
一种新的代谢产物--毛蕊素A与已知的化合物毛蕊素B一起从最初从海胆毛蕊弓孢菌（Toxopneustes pileolus）获得的烟曲霉菌株中分离得到。基于光谱分析，包括1D和2D NMR技术，确定了毛蕊素A的相对立体结构。这种独特的吡啶并-α-吡喃酮倍半萜类代谢物在C-4位具有螺-δ-内酯。(C)2012爱思唯尔有限公司保留所有权利。
A new metabolite, pileotin A, was isolated from a strain of Aspergillus fumigatus originally obtained from the sea urchin Toxopneustes pileolus together with the known compound oxalicine B. The relative stereo-structure of pileotin A was elucidated based on spectroscopic analyses, including 1D and 2D NMR techniques. This unique pyridino-alpha-pyrone sesquiterpene type metabolite has spiro-delta-lactone at C-4. (C) 2012 Elsevier Ltd. All rights reserved.