Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8.
Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8.
复制标题
DOI：
10.1186/ar149
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Lipsky PE
中科院分区：
文献类型：
--
作者：
Hayashida K;Nanki T;Girschick H;Yavuz S;Ochi T;Lipsky PE
类风湿关节炎患者滑膜中积聚的巨噬细胞在这种炎症性疾病的发病机制中发挥着重要作用。然而，巨噬细胞被吸引到发炎滑膜并在那里积聚的机制尚未完全阐明。本研究结果表明，类风湿性关节炎滑膜基质细胞产生趋化因子单核细胞趋化蛋白1和IL-8，它们具有吸引外周单核细胞的能力。这些结果表明，巨噬细胞在发炎滑膜中积聚的机制之一是响应局部产生的趋化因子。
Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.
登录
查看更多内容
影响因子：
15.3
作者：
Gong, JH;Ratkay, LG;Waterfield, JD;ClarkLewis, I
通讯作者：
ClarkLewis, I
影响因子：
15.9
作者：
Johnston, B;Burns, AR;Kubes, P
通讯作者：
Kubes, P
影响因子：
4.4
作者：
Hayashida, K;Shimaoka, Y;Lipsky, PE
通讯作者：
Lipsky, PE
影响因子：
4.4
作者：
PlaterZyberk, C;Hoogewerf, AJ;Wells, TNC
通讯作者：
Wells, TNC
影响因子：
15.9
作者：
Shimaoka, Y;Attrep, JF;Lipsky, PE
通讯作者：
Lipsky, PE