Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
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DOI：
10.1016/j.ymeth.2005.10.003
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发表时间：
2006-02-01
期刊：
影响因子：
4.8
通讯作者：
Oh, YK
中科院分区：
文献类型：
--
作者：
Han, IK;Kim, YB;Oh, YK
粘液瘤疫苗接种正在成为一种潜在的管理途径，引发抗原特异性粘膜和全身免疫原性。大多数粘膜疫苗在磷酸盐缓冲盐水载体中施用，这可能限制抗原暴露于粘膜表面并导致免疫原性差。为了提高粘膜疫苗的效力，我们已经开发了粘膜疫苗递送系统，其可以防止泄漏并增加疫苗在粘膜表面上的保留。热敏性聚合物已用于减少鼻或阴道疫苗的渗漏问题，而粘膜粘附聚合物已用于增加疫苗的粘膜接触。在这里，我们描述了使用热敏性和粘膜粘附性聚合物的粘膜疫苗的制剂和递送方法。(c)2005年爱思唯尔公司All rights reserved.
Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers. (c) 2005 Elsevier Inc. All rights reserved.