Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation
Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation
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DOI：
10.1523/jneurosci.0325-07.2007
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发表时间：
2007-04-25
影响因子：
5.3
通讯作者：
Nicoll, Roger A.
中科院分区：
文献类型：
--
作者：
Adesnik, Hillel;Nicoll, Roger A.
海马突触的长期增强（LTP）被认为与AMPA受体插入突触后膜有关。关于在LTP过程中是否插入钙渗透受体，以及是否需要新插入的AMPA受体介导的突触活动来维持突触强度的增加，存在相互矛盾的证据。在这里，我们严格地测试了这些假设，并得出结论，钙渗透性AMPA受体在LTP期间不插入，也不需要持续的活性维持。
Long-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.