Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.
Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.
复制标题
精浆中的锌水平及其与男性不育的相关性：系统评价和荟萃分析
DOI：
10.1038/srep22386
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发表时间：
2016-03-02
影响因子：
4.6
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Zhao J;Dong X;Hu X;Long Z;Wang L;Liu Q;Sun B;Wang Q;Wu Q;Li L
锌是男性生殖系统正常运作所必需的微量矿物质。目前的研究探讨了精浆锌与男性不育的关系，但结果不一致。因此，我们系统地检索了PubMed、EMBASE、Science Direct/Elsevier、CNKI和科克伦图书馆，以了解精浆锌与男性不育之间的关系以及补锌对精子参数的影响。共确定了20项研究，包括2，600例病例和867例对照。我们的荟萃分析结果表明，不育男性的精浆锌浓度显著低于正常对照组（SMD（标准均值差）[95% CI]-0.64 [-1.01，-0.28]）。研究发现，补充锌可显著增加精液量、精子活力和正常精子形态的百分比（SMD [95%CI]：分别为-0.99 [-1.60，-0.38]、-1.82 [-2.63，-1.01]和-0.75 [-1.37，-0.14]）。本研究表明，不育男性精浆锌含量明显低于正常男性。补充锌能显著提高不育男性的精子质量。然而，精浆锌与男性不育的相关性还有待进一步研究。
Zinc is an essential trace mineral for the normal functioning of the male reproductive system. Current studies have investigated the relationship between seminal plasma zinc and male infertility but have shown inconsistent results. Hence, we systematically searched PubMed, EMBASE, Science Direct/Elsevier, CNKI and the Cochrane Library for studies that examined the relationship between seminal plasma zinc and male infertility, as well as the effects of zinc supplementation on sperm parameters. Twenty studies were identified, including 2,600 cases and 867 controls. Our meta-analysis results indicated that the seminal plasma zinc concentrations from infertile males were significantly lower than those from normal controls (SMD (standard mean differences) [95% CI] −0.64 [−1.01, −0.28]). Zinc supplementation was found to significantly increase the semen volume, sperm motility and the percentage of normal sperm morphology (SMD [95% CI]: −0.99 [−1.60, −0.38], −1.82 [−2.63, −1.01], and −0.75 [−1.37, −0.14], respectively). The present study showed that the zinc level in the seminal plasma of infertile males was significantly lower than that of normal males. Zinc supplementation could significantly increase the sperm quality of infertile males. However, further studies are needed to better elucidate the correlation between seminal plasma zinc and male infertility.