Emerging pharmacological strategies in the fight against cocaine addiction.
Emerging pharmacological strategies in the fight against cocaine addiction.
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DOI：
10.1517/14728214.11.1.91
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发表时间：
2006-03-01
影响因子：
3.4
通讯作者：
Kosten, Thomas R
中科院分区：
文献类型：
--
作者：
Sofuoglu, Mehmet;Kosten, Thomas R
可卡因成瘾仍然是全世界一个重要的公共卫生问题。目前，没有经证实的药物治疗可卡因成瘾的方法。这里回顾的研究揭示了一些新的可卡因药物治疗靶点。首先，二硫仑，一种具有多巴胺能作用的药物，在许多临床试验中减少了可卡因的使用。第二，GABA药物，替加滨和托吡酯，在临床试验中被发现有前景。第三，一种-肾上腺素能阻滞剂，心得安，尤其对戒断严重程度高的可卡因成瘾者可能有效。第四，兴奋剂莫达非尼的治疗减少了可卡因的使用。最后，一种减缓可卡因进入大脑的可卡因疫苗带来了希望。这些有希望的发现需要在对照临床试验中进一步检验。
Cocaine addiction continues to be an important public health problem worldwide. At present, there are no proven pharmacotherapies for cocaine addiction. The studies reviewed here revealed a number of emerging targets for cocaine pharmacotherapy. First, disulfiram, a medication with dopaminergic effects, reduced cocaine use in a number of clinical trials. Second, GABA medications, tiagabine and topiramate, were found promising in clinical trials. Third, a beta-adrenergic blocker, propranolol, may be effective especially among cocaine-addicted individuals with high withdrawal severity. Fourth, treatment with a stimulant medication, modafinil, has reduced cocaine use. Last, a cocaine vaccine that slows entry of cocaine into the brain holds promise. These promising findings need to be further tested in controlled clinical trials.