Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour.
Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour.
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DOI：
10.1038/bjc.1977.160
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发表时间：
1977-07
影响因子：
8.8
通讯作者：
Steel, G G
中科院分区：
文献类型：
--
作者：
Stanley, J A;Shipley, W U;Steel, G G
已经获得了大小从 0-5 到 20 mm3 的肺部 Lewis 肺肿瘤的辐射生存曲线，并发现了缺氧分数的大小依赖性变化。不同大小的皮下细胞治疗后的细胞存活研究肿瘤表明 60Co 伽马射线和化疗剂 1,3-bas(2-氯乙基)-1-亚硝基脲 (BCNU) 和环磷酰胺的作用均依赖于大小。已经消退但尚未被环磷酰胺治愈的大肺结节重新生长，具有先前未经治疗的肿瘤所特有的放射敏感性。这些结果为微转移的早期辅助治疗和较大肿瘤的序贯联合疗法的临床兴趣提供了额外的实验支持。
Radiation survival curves for Lewis lung tumours in the lungs ranging in size from 0-5 to 20 mm3 have been obtained, and a size-dependent variation in hypoxic fraction was found. Cell-survival studies following treatment of various sizes of s.c. tumours indicated that the effects of 60Co gamma-rays and the chemotherapeutic agents 1,3-bas(2-chloroethyl)-1-nitrosourea (BCNU) and cyclophosphamide are all size-dependent. Large pulmonary nodules which had regressed but had not been cured by cyclophosphamide regrew with a radiosensitivity that was characteristic of previously untreated tumours. The results give additional experimental support to the clinical interest in early adjuvant therapy of micrometastases, and sequential combined modality therapy for larger tumours.