Allelic loss in chromosomal region 1q21-23 in breast cancer is associated with peritumoral angiolymphatic invasion and extensive intraductal component
Allelic loss in chromosomal region 1q21-23 in breast cancer is associated with peritumoral angiolymphatic invasion and extensive intraductal component
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DOI：
10.1053/ejso.1999.0921
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发表时间：
2000-08-01
期刊：
影响因子：
--
通讯作者：
Spandidos, DA
中科院分区：
文献类型：
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作者：
Gaki, V;Tsopanomichalou, M;Spandidos, DA
目的：乳腺癌是女性人群中最常见的癌症，染色体改变常与癌症的发生有关。方法：采用聚合酶链式反应(PCR)技术，对50例可手术乳腺癌患者的肿瘤、相应的正常组织和外周血标本进行1号染色体长臂和短臂16个DNA多态标记的检测。结果：1号染色体1q21-23区域与广泛导管成分(EIC)的存在和肿瘤周围血管淋巴管(PALI)的侵袭密切相关；结论：1q21-23区域的等位基因缺失与其他组织学和临床指标相结合，可作为判断乳腺癌局部复发的有价值的生物学指标。(C)2000 HarCourt出版有限公司。
Aims: Breast cancer is the most frequent cancer in the female population and the involvement of chromosomal alterations is often implicated in the development of cancer. The aim of our study was to assess loss of heterozygosity (LOH) in chromosome 1 in relation to clinical and pathological parameters.Methods: Tumours, corresponding normal tissues and peripheral blood samples from 50 women with operable breast cancer, were analysed by polymerase chain reaction (PCR) at 16 polymorphic DNA markers, on both the long and short arm of chromosome 1.Results: There was a significant correlation between chromosomal region 1q21-23 and the presence of extensive intraductal component (EIC) and peritumoral angiolymphatic (PALI) invasion, both independent markers of local recurrence.Conclusions: Allelic loss in region 1q21-23 may be a valuable prognostic biological marker for the detection of local relapse in breast cancer, in combination with other histological and clinical parameters. (C) 2000 Harcourt Publishers Ltd.