Relative risk of neurological signs in siblings of patients with schizophrenia
Relative risk of neurological signs in siblings of patients with schizophrenia
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DOI：
10.1176/appi.ajp.158.11.1827
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发表时间：
2001-11-01
影响因子：
17.7
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Egan, MF;Hyde, TM;Weinberger, DR
目的：精神分裂症患者的一级亲属似乎有微妙的神经症状，这表明这些指标可以作为精神分裂症遗传研究的中间表型。然而，一种可能的遗传成分的强度是未知的，因此不确定这些特征是否能增加发现精神分裂症易感位点的能力。作者的目标是调查这种可能的遗传成分的强度。方法：他们估计了一大群精神分裂症患者的兄弟姐妹神经损伤的相对风险。采用两种标准神经学量表（神经学评估量表和伍兹量表）对115例患者、185例其兄弟姐妹和88例正常对照者进行了检查。结果：精神分裂症患者的兄弟姐妹仅在伍兹量表上与正常对照组有显著差异。兄弟姐妹组神经功能损害的相对危险度显著增加，但显著性为弱至中度。神经损伤与其他几种基于认知损伤的中间表型测量并不多余。结论：这些数据表明，精神分裂症患者及其家庭的神经症状聚集，可能确定精神分裂症风险遗传变异的独特组成部分。然而，相对较低的风险和不确定的病理生理可能会限制这些迹象的有用性。
Objective: First-degree relatives of patients with schizophrenia appear to have subtle neurological signs, suggesting that these measures could serve as intermediate phenotypes in genetic studies of schizophrenia. The strength of a possible genetic component is unknown, however, leaving it uncertain whether such traits could increase the power to find schizophrenia susceptibility loci. The authors' goal was to investigate the strength of this possible genetic component.Method: They estimated the relative risk of neurological impairments in a large group of siblings of patients with schizophrenia. Two standard neurological scales (the Neurological Evaluation Scale and the Woods Scale) were used to examine 115 patients, 185 of their siblings, and 88 normal comparison subjects.Results: There were significant differences between the siblings of patients with schizophrenia and the normal comparison subjects only on the Woods Scale. Relative risk of neurological impairment was significantly increased in the sibling group, but the significance was weak to moderate. Neurological impairment was not redundant with several other intermediate phenotypic measures based on cognitive impairment.Conclusions: These data suggest that neurological signs cluster in patients with schizophrenia and their families and could possibly identify a unique component of genetic variance for risk of schizophrenia. However, the fairly low relative risk and the uncertain pathophysiology of such signs may limit their usefulness.