Simultaneous 18F-FDG-PET/MRI: Associations between diffusion, glucose metabolism and histopathological parameters in patients with head and neck squamous cell carcinoma
Simultaneous 18F-FDG-PET/MRI: Associations between diffusion, glucose metabolism and histopathological parameters in patients with head and neck squamous cell carcinoma
复制标题
同时 18F-FDG-PET/MRI： 头颈部鳞状细胞癌患者的弥散、葡萄糖代谢和组织病理学参数之间的关系
DOI：
10.1016/j.oraloncology.2016.04.009
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发表时间：
2016-07-01
期刊：
影响因子：
4.8
通讯作者：
Purz, Sandra
中科院分区：
文献类型：
--
作者：
Surov, Alexey;Stumpp, Patrick;Purz, Sandra
Objectives: To analyze possible associations between functional simultaneous F-18-FDG-PET/MR imaging parameters and histopathological parameters in head and neck squamous cell carcinoma (HNSCC).Material and Methods: 11 patients (2 female, 9 male; mean age 56.0 years) with biopsy-proven primary HNSCC underwent simultaneous F-18- FDG-PET/MRI with a dedicated head and neck protocol including diffusion weighted imaging. For each tumor, glucose metabolism was estimated with standardized uptake values (SUV) and diffusion restriction was calculated using apparent diffusion coefficients (ADC).The tumor proliferation index was estimated on Ki 67 antigen stained specimens. Cell count, total nucleic area, and average nucleic area were estimated in each case. Pearson's correlation coefficient was used to analyze possible associations between the estimated parameters.Results: The mean SUVmax value was 24.41 +/- 6.51, and SUVmean value 15.01 +/- 4.07. Mean values (x10 (3) mm(2) s (1)) of ADC parameters were as follows: ADC(min): 0.65 +/- 0.20; ADC(mean): 1.28 +/- 0.18; and ADC(max): 2.16 +/- 0.35. Histopathological analysis identified the following results: cell count 1069.82 +/- 388.66, total nucleic area 150771.09 +/- 61177.12 mu m(2), average nucleic area 142.90 +/- 57.27 mu m(2) and proliferation index 49.09 +/- 22.67%. ADC(mean) correlated with Ki 67 level (r = -0.728, p = 0.011) and total nucleic area (r = -0.691, p = 0.019) and tended to correlate with average nucleic area (r = -0.527, p = 0.096). ADC(max) correlated with Ki 67 level (r = -0.633, p = 0.036). SUVmax also tended to correlate with average nucleic area (r = 0.573, p = 0.066). Combined parameter SUVmax/ADC(min) correlated with average nucleic area (r = 0.627, p = 0.039).Conclusion: ADC and SUV values showed significant correlations with different histopathological parameters and can be used as biological markers in HNSCC. (C) 2016 Elsevier Ltd. All rights reserved.
