Auditory comprehension of language in young children - Neural networks identified with fMRI
Auditory comprehension of language in young children - Neural networks identified with fMRI
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DOI：
10.1212/01.wnl.0000059865.32155.86
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发表时间：
2003-05-27
期刊：
影响因子：
9.9
通讯作者：
Gaillard, WD
中科院分区：
文献类型：
--
作者：
Ahmad, Z;Balsamo, LM;Gaillard, WD
目的：对幼儿语言处理神经系统的组织结构知之甚少。作者使用功能磁共振成像来识别健康幼儿听觉理解的大脑区域。方法：15名右利手儿童（平均年龄6.8岁）在1.5-T使用血氧水平依赖性回波平面成像进行fMRI。他们听的故事有反向言语控制条件。组数据用统计参数图进行分析。采用基于t图的感兴趣区域方法分析个体受试者数据。计算每个区域的不对称指数（AI = [（L-R）/（L+R）]）。结果如下：分组分析显示，沿着上级颞上沟向后延伸至角回（BA 39）的左侧颞中回（Brodmann区[BA] 21）和左侧上级颞上回（BA 22）显著激活。个体标测图显示颞区激活偏侧化（AI > 0.49 +/- 0.39）。额叶有轻微的活动。年龄与区域AI无显著相关性。结论：听觉语言处理的网络在5岁时是局部化和偏侧化的。这些数据可以提供一种方法来解释语言功能磁共振成像研究进行准备脑手术，并可用于调查慢性疾病状态，如癫痫，在关键时期的可塑性语言组织的影响。
Objective: The organization of neuronal systems that process language in young children is poorly understood. The authors used fMRI to identify brain regions underlying auditory comprehension in healthy young children. Methods: Fifteen right-handed children (mean age 6.8 years) underwent fMRI at 1.5-T using blood oxygen level dependent echoplanar imaging. They listened to stories with a reverse speech control condition. Group data were analyzed with statistical parametric mapping. Individual subject data were analyzed with a region of interest approach based on t-maps. An asymmetry index (AI = [(L-R)/(L+R)]) was calculated for each region. Results: Group analysis showed significant activation in the left middle temporal gyrus (Brodmann area [BA] 21) and left superior temporal gyrus (BA 22) along the superior temporal sulcus extending back to the angular gyrus (BA 39). Individual maps showed lateralized activation in temporal regions (AI > 0.49 +/- 0.39). There was minimal activation in the frontal lobe. There were no significant correlations between age and regional AI. Conclusion: Networks for auditory language processing are regionally localized and lateralized by age 5. These data may provide a means to interpret language fMRI studies performed in preparation for brain surgery, and may be employed to investigate the effect of chronic disease states, such as epilepsy, on language organization during critical periods for plasticity.