Thyroid transcription factor-1
Thyroid transcription factor-1
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DOI：
10.1016/s1357-2725(97)00007-1
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发表时间：
1997-12-01
影响因子：
4
通讯作者：
Bingle, CD
中科院分区：
文献类型：
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作者：
Bingle, CD
甲状腺转录因子-1(TTF-1)是新近发现的同源结构域转录因子家族成员，在调节甲状腺、肺和脑中表达的基因，包括甲状腺球蛋白、甲状腺过氧化物酶、Clara细胞分泌蛋白和表面活性蛋白，更多的研究，包括基因打靶实验，已经清楚地表明TTF-1的表达对于甲状腺、肺和腹侧前脑的形态发生是必不可少的，因为TTF-1基因敲除的小鼠缺乏这些器官，根据这些研究，TTF-1的突变似乎可能是这些器官系统器官发生或细胞功能异常的基础。最近的一个这种缺陷的例子是一名由于TTF-1表达减少而导致甲状腺球蛋白缺乏症的患者。版权所有(C)1997爱思唯尔科学有限公司。保留所有权利。
Thyroid transcription factor-1 (TTF-1) is a recently identified member of the homeodomain transcription factor family, which plays a role in regulating genes expressed within the thyroid, lung and brain, including thyroglobulin, thyroid peroxidase, Clara cell secretory protein and the surfactant proteins, Additional studies, including gene targeting experiments, have clearly shown that expression of TTF-1 is essential for morphogenesis of the thyroid, lung and ventral forebrain, as TTF-1 knockout mice lack these organs, In the light of these studies it seems possible that mutations in TTF-1 may underlie certain abnormalities either of organogenesis of, or of cellular function within, these organ systems. A recent example of such a defect is the identification of a patient with thyroglobulin deficiency due to decreased TTF-1 expression. Copyright (C) 1997 Elsevier Science Ltd. All rights reserved.