FRUCTOSE-BISPHOSPHATE ALDOLASES - AN EVOLUTIONARY HISTORY
FRUCTOSE-BISPHOSPHATE ALDOLASES - AN EVOLUTIONARY HISTORY
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DOI：
10.1016/0968-0004(92)90247-7
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发表时间：
1992-03-01
影响因子：
13.8
通讯作者：
LEBHERZ, HG
中科院分区：
文献类型：
--
作者：
MARSH, JJ;LEBHERZ, HG
已知存在两种不同形式的果糖-二磷酸缩醛酶。人们一直认为，II类(金属)醛缩酶在进化上比它们的I类(席夫碱)类似物更原始，因为后者只在真核生物中发现。随着原核生物I类醛缩酶的鉴定，我们提出了一种替代的醛缩酶进化方案。这一方案提出，这两种醛缩酶类型在进化上都是古老的，并使观察到的两种酶类型在当代生命形式中高度可变的表达合理化。
Two mechanistically distinct forms of fructose-bisphosphate aldolase are known to exist. It has been assumed that the Class II (metallo) aldolases are evolutionarily more primitive than their Class I (Schiff-base) analogs since the latter had only been found in eukaryotes. With the identification of prokaryotic Class I aldolases, we present here an alternative scheme of aldolase evolution. This scheme proposes that both aldolase classes are evolutionarily ancient and rationalizes the observed highly variable expression of both enzyme types in contemporary life forms.