Inhibition of human neutrophil chemotaxis in vitro by phenothiazines and related compounds
Inhibition of human neutrophil chemotaxis in vitro by phenothiazines and related compounds
复制标题
吩噻嗪及相关化合物体外抑制人中性粒细胞趋化性
DOI：
10.1128/iai.14.4.948-950.1976
复制
发表时间：
1976
影响因子：
3.1
通讯作者：
P. Quie
中科院分区：
文献类型：
--
作者：
B. Björkstén;P. Quie
Chlorpromazine (CPZ) and three other phenothiazines and the structurally related antidepressant drugs imipramine and amitriptyline were found to depress human neutrophil chemotactic responsiveness. A 7 X 10(-6)M solution of CPZ inhibited chemotaxis, whereas concentrations of the other tested drugs 10 to 1,000 times greater than this were needed to inhibit chemotaxis. This effect of CPZ could not, however, be demonstrated when testing neutrophils from patients treated with the drug. The inhibition of chemotaxis was reversible when CPZ-incubated neutrophils were washed before testing for chemotactic responsiveness. CPZ affects neutrophil funcjtion as well as other aspects of immune response.
