AN EXPERIMENTAL-MODEL FOR MYOCARDITIS AND CONGESTIVE-HEART-FAILURE AFTER RABBIT CORONAVIRUS INFECTION
AN EXPERIMENTAL-MODEL FOR MYOCARDITIS AND CONGESTIVE-HEART-FAILURE AFTER RABBIT CORONAVIRUS INFECTION
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DOI：
10.1093/infdis/165.1.134
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发表时间：
1992-01-01
影响因子：
6.4
通讯作者：
BARIC, RS
中科院分区：
文献类型：
--
作者：
EDWARDS, S;SMALL, JD;BARIC, RS
在病毒诱导的心肌炎和充血性心力衰竭模型中，根据死亡日期和病理结果将兔冠状病毒感染分为急性期（2-5天）和亚急性期（6-12天）。 在急性期，主要的组织学病变是肌细胞变性和坏死、肌细胞溶解、间质水肿和出血。 这些变化的严重程度在亚急性期增加。 此时还出现胸腔积液和肺和肝充血。 第9天检测到心肌炎，第12天达到峰值。 心脏重量和心脏重量与体重的比值增加，右心室腔扩张在感染早期变得突出并持续存在。 相反，左心室扩张发生在亚急性期晚期。 在第2天至第12天之间从感染的心脏分离病毒。 这些数据表明，兔冠状病毒感染进展为心肌炎和充血性心力衰竭。
In a model for virus-induced myocarditis and congestive heart failure, rabbit coronavirus infection was divided into acute (days 2-5) and subacute (days 6-12) phases on the basis of day of death and pathologic findings. During the acute phase, the principal histologic lesions were degeneration and necrosis of myocytes, myocytolysis, interstitial edema, and hemorrhage. The severity of these changes increased in the subacute phase. Pleural effusion and congestion of the lungs and liver were also present at this time. Myocarditis was detected by day 9 and peaked by day 12. Heart weights and heart weight-to-body weight ratios were increased, and dilation of the right ventricular cavity became prominent early in infection and persisted. In contrast, dilation of the left ventricle occurred late in the subacute stage. Virus was isolated from infected hearts between days 2 and 12. These data suggest that rabbit coronavirus infection progresses to myocarditis and congestive heart failure.