Significant increase of oral bacteria in the early pregnancy period in Japanese women
Significant increase of oral bacteria in the early pregnancy period in Japanese women
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DOI：
10.1111/jicd.12189
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发表时间：
2017-02-01
影响因子：
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通讯作者：
Noguchi, Mayumi
中科院分区：
文献类型：
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作者：
Fujiwara, Natsumi;Tsuruda, Keiko;Noguchi, Mayumi
目的：孕期口腔微生物区系对母子口腔保健至关重要。我们检测了孕期和非孕期口腔微生物区系的变化。方法：以广岛市Asa市民医院登记的132名健康孕妇为研究对象，以51名健康非孕妇女为对照。对132例受试者在妊娠早期(7-16周)、中期(17-28周)和晚期(2939周)进行了7种微生物的培养和聚合酶链式反应检测。孕妇完成了一系列关于口腔和全身健康及生活习惯的问卷调查。结果：妊娠早期的可培养微生物总数显著高于非妊娠妇女(P<；0.05)。早中期妊娠组牙龈沟中的牙龈卟啉单胞菌和伴生放线杆菌的发生率显著高于非妊娠组(P<；0.05)，而中间普氏杆菌和核梭杆菌的发生率无明显变化。结论：妊娠，尤其是妊娠早期，促进了口腔微生物的增殖，促进了牙周病原菌的定植。
Aim: Oral microflora during pregnancy is critical to oral health care in the mother and her child. We examined the changes in the oral microbiota between pregnancy and nonpregnancy periods.Methods: The study was performed using 132 healthy pregnant women enrolled from Hiroshima City Asa Citizens Hospital and 51 healthy nonpregnant women as control. During pregnancy, 132 subjects were assessed for seven microbial species by the cultured method and polymerase chain reaction at the early (7-16 weeks gestation), the middle (17-28 weeks), and the late (2939 weeks) pregnancy periods. Pregnant women completed a series of questionnaires regarding oral and systemic health and lifestyle habits.Results: The total cultivable microbial counts in the early pregnancy were significantly higher than that of the nonpregnant women (P < 0.05). The incidences of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in gingival sulcus during the early and middle pregnancy were significantly higher than the nonpregnant group (P < 0.05), while Prevotella intermedia and Fusobacterium nucleatum did not change. Candida species were more frequently detected during the middle and late pregnancy.Conclusion: The data suggest that pregnancy, especially in the early periods, promotes the proliferation of microorganisms in the oral cavity and facilitates a colonization of periodontal pathogens.