In vitro and in vivo properties study of a novel 3D-printed absorbable pancreaticojejunostomy device made by melting blended poly(p-dioxanone)/poly(lactic acid)
In vitro and in vivo properties study of a novel 3D-printed absorbable pancreaticojejunostomy device made by melting blended poly(p-dioxanone)/poly(lactic acid)
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DOI：
10.1016/j.matdes.2021.110088
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发表时间：
2021-09-06
影响因子：
8.4
通讯作者：
Huang, Heguang
中科院分区：
文献类型：
--
作者：
Pan, Maoen;Xu, Zeya;Huang, Heguang
本研究将聚对二氧环酮（PPDO）与聚乳酸（PLA）熔融共混，制备PPDO/PLA共混物，并利用3D打印技术制备个性化胰空肠吻合术装置。通过体外和体内降解性能、力学性能、热稳定性、生物相容性、亲水性和细胞粘附性测试，选择合适比例的PPDO/PLA作为胰空肠吻合术装置材料。结果表明，采用熔丝制造（FFF） 3D打印技术，PPDO/PLA共混材料可制成胰空肠吻合术装置。随着PPDO比例的增加，其降解率逐渐提高，亲水性提高，更有利于细胞粘附和增殖，而其力学性能逐渐降低。但与软组织相比，仍可提供较长期的支撑强度，避免早期吻合口狭窄。体内质量损失率明显快于体外，3个月时50% PPDO/PLA的降解率为46.04 +/- 5.79%。随着降解产物的吸收和代谢，对人体重要器官无明显毒性。因此，50% PPDO/ PLA具有合适的降解时间、力学性能和良好的生物相容性，在制造3D胰空肠造口装置方面具有很大的应用潜力。(c) 2021年Elsevier Ltd.出版这是一篇基于CC BY-NC-ND许可（http:// creativecommons.org/licenses/by-nc-nd/4.0/）的开放获取文章。
Poly (p-dioxanone) (PPDO) and poly (lactic acid) (PLA) were melt blended to prepare PPDO/PLA blends in this study, and 3D printing technology was used to prepare personalized pancreaticojejunostomy devices. By testing the degradation properties, mechanical properties, thermal stability, biocompatibility, hydrophilicity, and cell adhesion in vitro and in vivo, a suitable ratio of PPDO/PLA was selected as the material for the pancreaticojejunostomy device. The results show that the pancreaticojejunostomy device can be fabricated by PPDO/PLA blends using fused filament fabrication (FFF) 3D printing. As the propor-tion of PPDO increases, its degradation rate gradually increases, and its hydrophilicity improves, which is more conducive to cell adhesion and proliferation, while its mechanical properties gradually decrease. However, compared with soft tissues, it can still provide longer-term support strength to avoid early anastomotic stenosis. The mass loss rate in vivo was significantly faster than that in vitro, and the degra-dation rate of 50% PPDO/PLA at 3 months was 46.04 +/- 5.79%. With the absorption and metabolism of the degradation products, there is no obvious toxic to the important organs in the body. Therefore, 50% PPDO/ PLA has a suitable degradation time, mechanical properties, and good biocompatibility and has great application potential in manufacturing 3D pancreaticojejunostomy devices. (c) 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).