Treatment of cancer with weekly intravenous 5‐fluorouracil
Treatment of cancer with weekly intravenous 5‐fluorouracil
复制标题
每周静脉注射 5-氟尿嘧啶治疗癌症
作者：
E. Jacobs;J. Luce;D. Wood
5-氟尿嘧啶通常通过快速静脉注射给药，每天15 mg/kg，持续3 - 5天，每2或3天7.5 mg/kg，每月重复一次（抗肿瘤反应约10-30%）。药物发病率和死亡率过高。对这一过程的修改显示出类似的反应率，但降低了毒性和死亡率。在本研究中，129例播散性癌症患者每周接受5-氟尿嘧啶治疗，无负荷剂量，通过快速静脉注射，从15 mg/kg/wk开始，持续1个月，增加至20 mg/kg/wk（如有必要）至产生轻度毒性或抗肿瘤作用的水平。30例患者客观缓解（占129例患者的23.3%，占91例充分治疗患者的33%）。38例患者显示无药物毒性，75例轻度，14例中度和2例重度毒性。没有药物死亡。该课程使患者能够在门诊基础上安全地接受治疗。
5‐Flourouracil is usually administered by rapid intravenous injection of 15 mg/kg daily for 3 to 5 days and 7.5 mg/kg every 2 or 3 days to toxicity, repeated monthly (antitumor response about 10–30%). Drug morbidity and mortality have been excessive. Modifications of this course have shown similar response rates but decreased toxicity and mortality. In the present study, 129 patients with disseminated cancer were treated weekly with 5‐fluorouracil, without a loading dose, by rapid intravenous injection, beginning at 15 mg/kg/wk for 1 month, increased to 20 mg/kg/wk (if necessary) to levels producing mild toxicity or an antitumor effect. Thirty patients had an objective remission (23.3% of the total 129, and 33% of the 91 adequately treated). Thirty‐eight patients showed no drug toxicity, 75 mild, 14 moderate, and two severe toxicity. There were no drug deaths. This course enabled patients to be treated safely on an ambulatory basis.