Postnatal weight and height growth velocities at different ages between birth and 5 y and body composition in adolescent boys and girls
Postnatal weight and height growth velocities at different ages between birth and 5 y and body composition in adolescent boys and girls
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DOI：
10.1093/ajcn/87.6.1760
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发表时间：
2008-06-01
影响因子：
7.1
通讯作者：
Charles, Marie-Aline
中科院分区：
文献类型：
--
作者：
Botton, Jeremie;Heude, Barbara;Charles, Marie-Aline
背景：出生头几年体重迅速增加与成人肥胖有关。这种长期影响是否存在关键的窗口期尚不清楚。目的：目的是根据出生至5岁之间不同年龄的体重和身高生长速度，按性别研究青春期的人体测量指标。设计：通过双足阻抗测量法测量468名8-17岁青少年的人体测量指标，包括脂肪和无脂肪质量。我们回顾性收集了早期婴儿数据，并使用数学模型单独估计了69.4%的青少年的体重和身高生长速度。研究了出生变量、生长速度和青春期人体测量指标之间的关系。结果：3月龄体重增长速度与青春期男女超重（1-SD增加的优势比：1.52;95% CI: 1.04, 2.22）、脂肪量和腰围相关，与男孩无脂肪量相关（r = 0.29, P < 0.001），但与女孩无关（r = -0.01，NS）。两岁后的体重增长速度与青春期所有人体测量值有关，男女皆是如此。在6个月至2岁之间，男孩的体重增长速度仅与青春期身高显著相关；在女孩中，与青春期脂肪量的关联较弱。结论：我们的研究结果支持儿童早期有两个关键窗口期与后期肥胖风险相关的假设：6个月和2岁以后。研究这两个时期的生长决定因素对于预防青少年肥胖具有重要意义。
Background: Rapid weight gain in the first years of life is associated with adult obesity. Whether there are critical windows for this long-term effect is unclear.Objective: The objective was to study anthropometric measures in adolescence by sex according to weight and height growth velocities at different ages between birth and 5 y.Design: Anthropometric measures, including fat and fat-free mass by bipodal impedancemetry, were measured in 468 adolescents aged 8-17 y. We retrospectively collected early infancy data and individually estimated weight and height growth velocities in 69.4% of them using a mathematical model. Associations between birth variables, growth velocities, and anthropometric measures in adolescence were studied.Results: Weight growth velocity at 3 mo was associated with overweight (odds ratio for a 1-SD increase: 1.52; 95% CI: 1.04, 2.22), fat mass, and waist circumference in adolescence in both sexes and with fat-free mass in boys (r = 0.29, P < 0.001) but not in girls (r = -0.01,NS). Weight growth velocities after 2 y were associated with all anthropometric measures in adolescence, in both sexes. Between 6 mo and 2 y, weight growth velocities were significantly associated only with adolescent height in boys; in girls, associations with fat mass in adolescence were weaker.Conclusion: Our results support the hypothesis of 2 critical windows in early childhood associated with the later risk of obesity: up to 6 mo and from 2 y onward. The study of the determinants of growth during these 2 periods is of major importance for the prevention of obesity in adolescence.