Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
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DOI：
10.1056/nejmoa1200111
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发表时间：
2012-04-26
影响因子：
158.5
通讯作者：
Rubino, Francesco
中科院分区：
文献类型：
--
作者：
Mingrone, Geltrude;Panunzi, Simona;Rubino, Francesco
背景Roux-en-Y胃转流术和胆胰分流术可显著改善病态肥胖患者的糖尿病，通常可导致疾病缓解。前瞻性，随机试验比较这些程序与药物治疗糖尿病是needed.MethodsIn这个单中心，非盲，随机，对照试验，60例患者的年龄在30和60岁之间的体重指数（BMI，体重（千克）除以身高（米）的平方）35或以上，至少5年糖尿病史，和糖化血红蛋白水平为7.0%或更高的患者被随机分配接受常规药物治疗或接受胃旁路术或胆胰分流术。主要终点是2年时糖尿病缓解率（定义为空腹血糖水平
BackgroundRoux-en-Y gastric bypass and biliopancreatic diversion can markedly ameliorate diabetes in morbidly obese patients, often resulting in disease remission. Prospective, randomized trials comparing these procedures with medical therapy for the treatment of diabetes are needed.MethodsIn this single-center, nonblinded, randomized, controlled trial, 60 patients between the ages of 30 and 60 years with a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of 35 or more, a history of at least 5 years of diabetes, and a glycated hemoglobin level of 7.0% or more were randomly assigned to receive conventional medical therapy or undergo either gastric bypass or biliopancreatic diversion. The primary end point was the rate of diabetes remission at 2 years (defined as a fasting glucose level of