Breast cancer microenvironment and obesity: challenges for therapy.
Breast cancer microenvironment and obesity: challenges for therapy.
复制标题
DOI：
10.1007/s10555-022-10031-9
复制
发表时间：
2022-09
影响因子：
9.2
通讯作者：
Arendt, Lisa M.
中科院分区：
文献类型：
--
作者：
Hillers-Ziemer, Lauren E.;Kuziel, Genevra;Williams, Abbey E.;Moore, Brittney N.;Arendt, Lisa M.
患乳腺癌的肥胖妇女预后更差，生存率降低，转移率增加。肥胖还与乳腺癌对内分泌和化疗治疗的反应降低有关。利用多种肥胖和人类乳腺肿瘤的体内模型的研究增强了我们对肥胖如何改变乳腺肿瘤微环境的理解。脂肪细胞、脂肪源性基质细胞、免疫细胞和内皮细胞的补体和功能的变化以及细胞外基质的重塑都有助于肥胖背景下乳腺肿瘤的快速生长。这些细胞的相互作用增强了乳腺肿瘤微环境中细胞因子和脂肪因子的分泌以及雌激素的局部水平，从而促进了对多种疗法的耐药性。在这篇综述中，我们将讨论我们目前对肥胖对乳腺肿瘤微环境的影响的理解，肥胖引起的细胞相互作用的变化如何促进对乳腺癌治疗的抵抗，以及肥胖乳腺癌患者治疗干预措施的发展领域。
Women with obesity who develop breast cancer have a worsened prognosis with diminished survival rates and increased rates of metastasis. Obesity is also associated with decreased breast cancer response to endocrine and chemotherapeutic treatments. Studies utilizing multiple in vivo models of obesity as well as human breast tumors have enhanced our understanding of how obesity alters the breast tumor microenvironment. Changes in the complement and function of adipocytes, adipose-derived stromal cells, immune cells, and endothelial cells and remodeling of the extracellular matrix all contribute to the rapid growth of breast tumors in the context of obesity. Interactions of these cells enhance secretion of cytokines and adipokines as well as local levels of estrogen within the breast tumor microenvironment that promote resistance to multiple therapies. In this review, we will discuss our current understanding of the impact of obesity on the breast tumor microenvironment, how obesity-induced changes in cellular interactions promote resistance to breast cancer treatments, and areas for development of treatment interventions for breast cancer patients with obesity.
登录
查看更多内容
影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
DOI：
10.1186/s13058-018-1029-4
发表时间：
2018-09-04
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bousquenaud M;Fico F;Solinas G;Rüegg C;Santamaria-Martínez A
通讯作者：
Santamaria-Martínez A
影响因子：
7.7
作者：
Alessi, MC;Bastelica, D;Juhan-Vague, I
通讯作者：
Juhan-Vague, I
影响因子：
11.2
作者：
Andarawewa, KL;Motrescu, ER;Rio, MC
通讯作者：
Rio, MC
影响因子：
5.3
作者：
Al-Khalaf, Huda H.;Amir, Mrad;Aboussekhra, Abdelilah
通讯作者：
Aboussekhra, Abdelilah