Utility of the LIBRA Index in Relation to Cognitive Functioning in a Clinical Health Seeking Sample
Utility of the LIBRA Index in Relation to Cognitive Functioning in a Clinical Health Seeking Sample
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DOI：
10.3233/jad-170731
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Naismith, Sharon L.
中科院分区：
文献类型：
--
作者：
Pons, Anke;LaMonica, Haley M.;Naismith, Sharon L.
背景：痴呆症的患病率预计将在未来几十年内大幅增加。由于目前没有治疗痴呆症的方法，因此迫切需要早期识别痴呆症高危人群，以便实施一级和二级预防战略。最近，BRAin健康生活方式（LIBRA）指数被开发为一种新的痴呆症风险算法。它特别关注可修改的风险和保护因素，可以针对在midlifes.Objective：本研究的目的是评估LIBRA指数在临床上，健康寻求样本的社区为基础的老年人的认知功能的标志物。方法：484名参与者（平均年龄62.7岁）被招募从健康的大脑衰老诊所在大脑和心灵中心，悉尼。参与者接受了全面的临床和神经心理学评估，并完成了自我报告调查包。参与者通过共识被评定为具有主观认知主诉（SCC）或符合轻度认知障碍（MCI）的标准。结果：65.4%的样本符合MCI的标准。MCI患者的LIBRA评分显著高于SCC患者。此外，多个认知领域，特别是执行功能，与更高的LIBRA评分，在人与MCI.Conclusion：LIBRA指数可能是一个有用的工具，以确定生活方式归因于认知能力下降的风险在老年人的健康寻求人口，包括MCI的人。
Background: Dementia prevalence is expected to increase substantially over the next few decades. Since there is currently no cure for dementia available, there is an urgent need for the early identification of individuals at high risk for dementia, so that primary and secondary prevention strategies can be implemented. Recently, the LIfestyle for BRAin health (LIBRA) index was developed as a new dementia risk algorithm. It specifically focuses on modifiable risk and protective factors that can be targeted in midlife.Objective: The objective of this study was to evaluate the LIBRA index in relation to markers of cognitive functioning in a clinical, health-seeking sample of community-based older adults.Methods: 484 participants (mean age 62.7 years) were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney. Participants underwent comprehensive clinical and neuropsychological assessment and completed a self-report survey pack. Participants were rated via consensus as having either subjective cognitive complaints (SCC) or meeting criteria for mild cognitive impairment (MCI). The LIBRA score was calculated based on 11 available risk and protective factors.Results: 65.4% of the sample met criteria for MCI. People with MCI showed a significantly higher LIBRA score compared to people with SCC. Furthermore, multiple cognitive domains, in particular executive functioning, were associated with a higher LIBRA score, with stronger correlations in people with MCI.Conclusion: The LIBRA index might be a useful tool to determine lifestyle-attributable risk of cognitive decline in an older health-seeking population, including people with MCI.