L1 Cell Adhesion Molecule (L1CAM) Expression at the Cancer Invasive Front Is a Novel Prognostic Marker of Pancreatic Ductal Adenocarcinoma
L1 Cell Adhesion Molecule (L1CAM) Expression at the Cancer Invasive Front Is a Novel Prognostic Marker of Pancreatic Ductal Adenocarcinoma
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DOI：
10.1002/jso.21880
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Kijima, Hiroshi
中科院分区：
文献类型：
--
作者：
Tsutsumi, Shinji;Morohashi, Satoko;Kijima, Hiroshi
背景与目的：胰腺导管腺癌（Pancreatic ductal adencarcinoma， PDAC）是最具侵袭性的肿瘤之一，根治性切除后预后较差。L1细胞粘附分子（L1 cell adhesion molecule, L1CAM）是一种200-220 kDa的I型跨膜糖蛋白，属于免疫球蛋白超家族，已被证明影响多种癌症的预后。L1CAM在PDAC侵袭前的表达未见临床病理意义。在本研究中，我们通过免疫组织化学检测了L1CAM表达与PDAC临床病理特征的关系。方法：应用抗L1CAM单克隆抗体对177例手术切除的PDAC标本进行免疫组化检测。结果：107例PDAC患者中有23例L1CAM阳性表达。在大多数情况下（21/23），L1CAM的表达局限于肿瘤组织的侵袭前部。L1CAM阳性表达与组织学分级、淋巴结累及及远处转移显著相关。在单因素分析中，L1CAM阳性表达与较短的总生存期相关（P = 0.0002），在多因素分析中，这是显著的（P = 0.009）。结论：体内L1CAM在PDAC侵袭过程中发挥重要作用，可作为判断PDAC预后的良好指标。[j] .中华外科杂志，2011;43(3):669-673。(C) 2011 Wiley-Liss, Inc。
Background and Objectives: Pancreatic ductal adenocarcinoma (PDAC) is one of the most extremely aggressive cancers with a poor prognosis after curative resection. L1 cell adhesion molecule (L1CAM) is a 200-220 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily, which has been shown to affect the prognosis of several cancers. No clinicopathological significance of L1CAM expression has been examined at the invasive front of PDAC. In this study, we examined the relationship between L1CAM expression and clinicopathological features in PDAC by immunohistochemistry.Methods: One hundred seven surgically resected specimens of PDAC were immunohistochemically examined using a monoclonal antibody against L1CAM.Results: Positive expression of L1CAM was found in 23 of 107 cases with PDAC. In most cases (21/23), L1CAM expression was localized at the invasive front of the tumor tissue. Positive expression of L1CAM was significantly correlated with the histological grade, lymph node involvement, and distant metastasis. In univariate analysis, a positive expression of L1CAM was associated with short overall survival (P = 0.0002), and this was significant in multivariate analysis (P = 0.009).Conclusions: L1CAM could play an important role in the invasive process in vivo, and is thought to be a good indicator of prognosis in PDAC. J. Surg. Oncol. 2011;103:669-673. (C) 2011 Wiley-Liss, Inc.