Diagnosis and treatment of depression in Alzheimer's disease - A practical update for the clinician
Diagnosis and treatment of depression in Alzheimer's disease - A practical update for the clinician
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DOI：
10.1159/000074277
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Lee, HCB
中科院分区：
文献类型：
--
作者：
Lyketsos, CG;Lee, HCB
超过80%的阿尔茨海默病（AD）患者在病程的某个阶段会出现“非认知”神经精神症状。抑郁症是最常见的合并症之一。抑郁症影响着多达50%的阿尔茨海默病患者，对患者和护理人员造成严重的负面影响。尽管阿尔茨海默病的表现不同于典型的“老年性”抑郁症，但它可以被可靠地检测和量化，并且可以与阿尔茨海默病的其他神经精神症状区分开来。阿尔茨海默病抑郁症的几种有效治疗方法是可用的。在许多情况下，这些措施减少了对患者和护理人员的不利影响。本文概述了目前有关阿尔茨海默病抑郁症的知识，供临床医生参考。随后对阿尔茨海默病中抑郁症的检测、评估、量化、鉴别诊断和治疗进行了实际探讨。版权所有(C) 2004 S. Karger AG，巴塞尔。
Over 80% of patients with Alzheimer's disease (AD) develop 'noncognitive' neuropsychiatric symptoms at some point during the course of their illness. Depression is among the most frequent of such comorbidities. Affecting up to 50% of AD patients, depression is associated with severe negative consequences for patients and caregivers. Despite having a presentation in the context of AD that differs from typical 'geriatric' depression, it can be detected and quantified reliably, and can be differentiated from the other neuropsychiatric symptoms of AD. Several effective treatment modalities for depression in AD are available. In many cases, these reduce its adverse impact on patients and caregivers. This paper provides an overview of current knowledge regarding depression in AD for the clinician. It is followed by a practical discussion of the detection, evaluation, quantification, differential diagnosis and treatment of depression in AD. Copyright (C) 2004 S. Karger AG, Basel.