OBESITY AND BODY-FAT DISTRIBUTION IN RELATION TO THE INCIDENCE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS - A PROSPECTIVE COHORT STUDY OF MEN IN THE NORMATIVE AGING STUDY
OBESITY AND BODY-FAT DISTRIBUTION IN RELATION TO THE INCIDENCE OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS - A PROSPECTIVE COHORT STUDY OF MEN IN THE NORMATIVE AGING STUDY
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DOI：
10.1093/oxfordjournals.aje.a116468
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发表时间：
1992-12-15
影响因子：
5
通讯作者：
WEISS, ST
中科院分区：
文献类型：
--
作者：
CASSANO, PA;ROSNER, B;WEISS, ST
在退伍军人事务部规范性老龄化研究队列的1,972名男性参与者中，前瞻性地评估了腹部体脂堆积、全身肥胖和血糖水平与非胰岛素依赖型糖尿病风险之间的关系。通过比例风险模型评估非胰岛素依赖型糖尿病的风险;在35，496人-年的观察中，1，972名男性（平均年龄41.9岁;范围22-80岁）中发生了226例糖尿病。体重指数与糖尿病风险的关系部分可以通过身体脂肪分布来解释;在调整年龄、腹围与臀宽之比和吸烟后，体重指数最高的三分之一男性患糖尿病的风险是最低三分之一男性的1.3倍（95%置信区间为0.9-1.8）。此外，在调整了年龄、体重指数和吸烟情况后，腹围与臀宽比值最高的三分位男性患糖尿病的风险是最低三分位男性的2.4倍（95%置信区间为1.7-3.7）。当血糖作为连续结果变量进行分析时，结果是一致的，即，与腹部脂肪的正相关性独立于全身肥胖。这些结果证实了以前的报告，腹部肥胖和糖尿病的风险之间的前瞻性关系，并提供了前瞻性的证据，血糖水平和体脂分布和肥胖之间的关系。
The relation between the abdominal accumulation of body fat, total-body adiposity, and blood glucose level and the risk of non-insulin-dependent diabetes mellitus was evaluated prospectively among 1,972 male participants in the Department of Veterans Affairs Normative Aging Study cohort. The risk of non-insulin-dependent diabetes mellitus was assessed by means of the proportional hazards model; 226 cases of diabetes occurred among the 1,972 men (mean age at entry, 41.9 years; range, 22-80 years) over 35,496 person-years of observation. The relation of body mass index to diabetes risk was partly explained by body fat distribution; after adjusting for age, the ratio of abdominal circumference to hip breadth, and cigarette smoking, men in the top tertile for body mass index had a 1.3-fold greater risk of diabetes than did men in the lowest tertile (95% confidence interval 0.9-1.8). Moreover, after adjusting for age, body mass index, and cigarette smoking, men in the top tertile for the ratio of abdominal circumference to hip breadth had a 2.4-fold greater risk of diabetes than did men in the lowest tertile (95% confidence interval 1.7-3.7). When blood glucose was analyzed as a continuous outcome variable, the findings were consistent, i.e., a positive association with abdominal fat independent of total-body adiposity. These results confirm previous reports of a prospective relation between abdominal adiposity and the risk of diabetes and provide prospective evidence of a relation between blood glucose levels and both body fat distribution and obesity.