Field Strength Dependence of R1 and R2* Relaxivities of Human Whole Blood to ProHance, Vasovist, and Deoxyhemoglobin
Field Strength Dependence of R1 and R2* Relaxivities of Human Whole Blood to ProHance, Vasovist, and Deoxyhemoglobin
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DOI：
10.1002/mrm.21792
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发表时间：
2008-12-01
影响因子：
3.3
通讯作者：
Gowland, P. A.
中科院分区：
文献类型：
--
作者：
Blockley, N. P.;Jiang, L.;Gowland, P. A.
本研究测量了Prol-lance（Gadoteridol）、Vasovist（Gado-fosveset）和脱氧血红蛋白在1.5、3.0和7.0特斯拉下的纵向和横向（T-2*）弛豫率曲线。R与造影剂和脱氧血红蛋白浓度的曲线呈线性关系。R-2* 与脱氧血红蛋白浓度的关系图显示二次依赖性。R2* 与造影剂浓度呈抛物线关系，最小值出现在造影剂浓度约为1.5 mM时，对应于体内可达到的浓度。进行Monte Carlo模拟以支持红细胞的敏感性与血浆的敏感性匹配的最小结果的假设。给出了所有试剂和所有三种场强的R-2* 和R的弛豫率值（s（-1）mM（-1））。Magn Reson Med 60：1313-1320，2008。(C)2008 Wiley-Liss，Inc.
This study has measured the longitudinal and transverse (T-2*) relaxivity curves for Prol-lance (Gadoteridol), Vasovist (Gado-fosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R, versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R-2* versus deoxyhemoglobin concentration showed a quadratic dependence. R2* versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s(-1) mM(-1)) for R-2* and R, for all agents and all three field strengths are given. Magn Reson Med 60:1313-1320, 2008. (C) 2008 Wiley-Liss, Inc.