Effects of nilvadipine, a calcium antagonist, on rabbit ocular circulation and optic nerve head circulation in NTG subjects.
Effects of nilvadipine, a calcium antagonist, on rabbit ocular circulation and optic nerve head circulation in NTG subjects.
复制标题
钙拮抗剂尼伐地平对 NTG 受试者兔眼循环和视神经乳头循环的影响。
DOI：
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发表时间：
1999
影响因子：
4.4
通讯作者：
Tetsuya Sugiyama
中科院分区：
文献类型：
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作者：
K. Tomita;M. Araie;Yasuhiro Tamaki;M. Nagahara;Tetsuya Sugiyama
目的
研究钙拮抗剂尼伐地平对兔视神经乳头（ONH）、脉络膜和视网膜组织循环的影响，以及对正常眼压性青光眼（NTG）患者ONH循环的影响。
方法
将尼伐地平（3.2 μ g/kg）或载体溶液静脉内注射到麻醉的家兔中，并使用激光散斑法在注射前和注射后90分钟在脉络膜和ONH和视网膜的无可见表面血管的区域中测量标准化模糊值（NB），其是体内组织血流速度的定量指标。尼伐地平对ONH循环的影响也进行了研究，使用氢气清除法在不同的家兔组。NTG患者以双盲方式口服尼伐地平（4 mg/d）或安慰剂，在给药前和给药后2、4、8和12周，用相同方法测量ONH边缘无可见表面血管区域的NB。
结果
与对照组的NB相比，尼伐地平组在实验期间从ONH、脉络膜或视网膜获得的NB增加了约10%至25%（P < 0.0001，方差分析），尽管全身状况参数和眼内压（IOP）除了尼伐地平组血压短暂下降外，没有显着的组间差异。通过H2气体清除法测定的ONH中的血流量也显示尼伐地平组增加约25%。在整个随访期间，与安慰剂治疗患者相比，口服尼伐地平治疗患者ONH中的NB显著增加约20%。在血压、脉率或IOP方面未观察到显著的组间差异。
结论
尼伐地平可增加兔ONH、脉络膜和视网膜的血流速度，可能还增加了血流量。它还增加了NTG患者ONH的血流速度。
PURPOSE
To study the effects of nilvadipine, a Ca2+ antagonist, on tissue circulation in the optic nerve head (ONH), choroid, and retina in rabbits and on the ONH circulation in normal tension glaucoma (NTG) patients.
METHODS
Nilvadipine (3.2 microg/kg) or vehicle solution was injected intravenously into urethane-anesthetized rabbits, and the normalized blur value (NB), a quantitative index of in vivo tissue blood velocity, was measured in the choroid and in an area of the ONH and retina free of visible surface vessels before and for 90 minutes after injection, using the laser speckle method. The effects of nilvadipine on the ONH circulation was also studied using the H2 gas clearance method in separate groups of rabbits. Oral nilvadipine (4 mg/d) or placebo was administered to NTG patients in a double-masked manner, and NB in an area of the ONH rim free of visible surface vessels was measured by the same method before and 2, 4, 8, and 12 weeks after administration.
RESULTS
The NB obtained from the ONH, choroid, or retina during the experimental period was increased by approximately 10% to 25% in the nilvadipine group compared with the NB in the control group (P < 0.0001, ANOVA), although systemic condition parameters and intraocular pressure (IOP) showed no significant intergroup difference except for a transient decrease in blood pressure in the nilvadipine groups. Blood flow rate in the ONH determined by the H2 gas clearance method also showed an approximately 25% increase in the nilvadipine group. The NB in the ONH of the oral nilvadipine-treated patients was significantly increased, by approximately 20% compared with the placebo-treated patients throughout the follow-up period. No significant intergroup difference was seen in blood pressure, pulse rate, or IOP.
CONCLUSIONS
Nilvadipine increased blood velocity and, probably, blood flow in the ONH, choroid, and retina of rabbits. It also increased blood velocity in the ONH of NTG patients.
猫静脉注射尼卡地平会增加视神经乳头，但不会增加视网膜血流量。
影响因子：
4.4
作者：
Harino,S;Riva,CE;Petrig,BL
通讯作者：
Petrig,BL
用碘安替比林测量视神经血流量：脉络膜扩散引起的限制。
影响因子：
3.4
作者：
Caprioli,J;Miller,JM
通讯作者：
Miller,JM