SELF-STIMULATION OF LATERAL HYPOTHALAMUS MODIFIED BY INSULIN AND GLUCAGON
SELF-STIMULATION OF LATERAL HYPOTHALAMUS MODIFIED BY INSULIN AND GLUCAGON
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DOI：
10.1016/0031-9384(67)90048-0
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发表时间：
1967-01-01
影响因子：
2.9
通讯作者：
HOEBEL, BG
中科院分区：
文献类型：
--
作者：
BALAGURA, S;HOEBEL, BG
在植入了下丘脑外侧电极的大鼠中，可以引起进食和自我刺激，皮下注射胰岛素可以增加自我刺激，而胰高血糖素可以减少自我刺激。当在一系列胰高血糖素注射后进行模拟注射时，也可以降低自我刺激率，这表明有条件反射效应。结论：控制血糖的胰腺激素可以影响下丘脑外侧奖赏功能。
In rats with implanted lateral hypothalamic electrodes which elicited feeding as well as self-stimulation, subcutaneous insulin injections increased self-stimulation, and glucagon decreased it. A decrease in self-stimulation rate was also obtained when a mock injection followed the series of glucagon injections, indicating a conditioning effect. It is concluded that pancreatic hormones which control blood sugar can influence lateral hypothalamic reward.