Risk factors in the development of cytomegalovirus-related pneumonia in renal transplant recipients.
Risk factors in the development of cytomegalovirus-related pneumonia in renal transplant recipients.
复制标题
肾移植受者发生巨细胞病毒相关肺炎的危险因素。
DOI：
10.1093/infdis/148.6.1121
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Simmons,RL
中科院分区：
文献类型：
--
作者：
Peterson,PK;BalfourJr,HH;Fryd,DS;Ferguson,R;Kronenberg,R;Simmons,RL
请注意。从1980年10月1日至1982年9月30日，明尼苏达大学医院为12岁的患者实施了213例肾移植。对这些患者进行前瞻性随访，直到1982年12月31日，发现24例(8.8%)受者出现肺炎。CMV与总共18次肺炎有关(其中4次还分离出其他病原体)；所有18名患者都至少有一次CMV阳性培养(13次为病毒型)，16例患者有记录的血清转换(诊断方法在其他地方描述[1])。对接受者的年龄、性别、是否患有糖尿病以及供受者关系的分析表明，这些因素都与巨细胞病毒相关肺炎的风险增加无关(P>；0.1；在所有比较中使用Yates‘s校正的X2检验)。*在两年的研究间隔中，152名接受者参加了环孢菌素加小剂量强的松与标准免疫抑制疗法(抗淋巴细胞球蛋白、硫唑嘌呤和强的松)的随机试验[2]。76名患者被分配到每个治疗组，两组在年龄、性别、基础疾病、供受者关系以及供受者CMV血清学状态方面具有可比性。对196例移植患者进行了移植前T供受者血清学状态的测定；阴性=CF抗体效价1：4；阳性=CF效价~1：4。
NOTE. Between October I, 1980, and September 30, 1982, 213 renal transplants were performed at the University of Minnesota Hospital in patients> 12years of age. These patients were followed prospectively through December 31, 1982, for the development of pneumonia, which was diagnosed in 24 (8.8%) of the recipients. CMV was associated with a total of 18 episodes of pneumonia (in four of which other pathogens were also isolated); all 18patients had at least one positive culture for CMV (13 were viremic), and seroconversion was documented in 16cases (diagnostic methods are described elsewhere [1)). Analysis of recipient age, sex, presence of diabetes mellitus, and donor-recipient relationship revealed that none of these factors was associated with an increased risk of CMV-related pneumonia (P> 0.1; X2 test with Yates's correction used for all comparisons).* During the two-year study interval, 152 recipients entered a randomized trial of cyclosporine plus low-dosage prednisone vs standard immunosuppressive therapy (antilymphocyte globulin, azothioprine, and prednisone)[2]. Seventy-six patients were allocated to each treatment group, and both groups were comparable as to age, sex, underlying disease, donor-recipient relationship, and CMV serologic status of donor and recipient. t Pretransplant donor/recipient serologic status was determined for 196 transplants; negative= CF antibody titer< 1: 4; positive= CF titer~ 1: 4.