Phenylephrine-induced activity in mice as a model of central α 1-adrenoceptor function Effects of acute and repeated administration of antidepressant drugs and electroconvulsive shock
Phenylephrine-induced activity in mice as a model of central α
1-adrenoceptor function Effects of acute and repeated administration of antidepressant drugs and electroconvulsive shock
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去氧肾上腺素诱导的小鼠中枢 α 1-肾上腺素受体功能模型的活性急性和重复施用抗抑郁药物和电惊厥休克的影响
DOI：
10.1016/0028-3908(84)90040-6
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发表时间：
1984
影响因子：
4.7
通讯作者：
D. Heal
中科院分区：
文献类型：
--
作者：
D. Heal
侧脑室注射α1受体激动剂苯肾上腺素（10-100 μg）或甲氧胺（10-50μg）可使小鼠自发活动和行为兴奋呈剂量依赖性增加。哌唑嗪可抑制苯异丙胺引起的综合征，但育亨宾、RX 781094或普萘洛尔则不能抑制。甲氧胺诱导的反应，然而，育亨宾也减少。苯乙哌啶醇诱导的活性不受甲麦角林或哌仑哌隆的影响，但氟哌啶醇和螺哌利多可降低活性。用α-甲基-p-酪氨酸或弗拉-63预处理可分别抑制自发活动或综合征的其他行为成分，从而减少对苯肾上腺素的反应。这表明，一些残留的去甲肾上腺素能和多巴胺能功能可能是必要的苯肾上腺素的影响的行为表达。米安色林和阿米替林可抑制该活性，但去甲丙咪嗪不抑制该活性。当这些抗抑郁药每天给药两次，持续14天，米安色林单独影响苯异黄酮诱导的活性，在最后一次注射后12或60小时进行测试。这种行为也没有改变24小时后，小鼠接受了电休克氟烷麻醉下，每天一次，共10 day.In的结论，数据表明，苯肾上腺素诱导的行为综合征可能提供了一个具体的和可量化的评估中枢α1-肾上腺素能受体的功能，并在一般情况下，这是不变的抗抑郁药或电休克反复给药。
Intracerebroventricular injection of theα1-agonists phenylephrine (10–100 μg) or methoxamine (10–50μg) produced a dose-dependent increase in locomotor activity and behavioural excitation in mice. The syndrome induced by phenylephrine was inhibited by prazosin but not yohimbine, RX 781094 or propranolol. Methoxamine-induced responses were, however, also reduced by yohimbine. Activity induced by phenylephrine was not affected by metergoline or pirenperone but was reduced by haloperidol and spiroperidol. This latter effect, however, may have been due to inhibition ofα1-adrenoceptors and/or dopamine receptors.Pretreatment with α-methyl-p-tyrosine or FLA-63 reduced responses to phenylephrine by respectively inhibiting either the locomotor activity or the other behavioural components of the syndrome. This suggests that some residual noradrenergic and possibly also dopaminergic function may be necessary for the behavioural expression of the effects of phenylephrine. The activity was inhibited by mianserin and amitriptyline but not by desmethylimipramine. When these antidepressant drugs were given twice daily for 14 days, mianserin alone affected the activity induced by phenylephrine, tested either 12 or 60 hr after the final injection. This behaviour was also not altered 24 hr after the mice had received an electro-convulsive shock under halothane anaesthesia, once daily for 10 days.In conclusion, the data suggest that the behavioural syndrome induced by phenylephrine probably provides a specific and quantifiable assessment of centralα1-adrenoceptor function and that in general this is unaltered following repeated administration of antidepressant drugs or electroconvulsive shock.
长期抗抑郁药治疗会降低螺哌啶醇标记的血清素受体结合。
DOI：
10.1126/science.6251550
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Peroutka,SJ;Snyder,SH
通讯作者：
Snyder,SH
新生儿 6-羟基多巴胺治疗后脑部 β-肾上腺素能受体的发育。
影响因子：
3.8
作者：
Lorton,D;Bartolome,J;Slotkin,TA;Davis,JN
通讯作者：
Davis,JN