Biological markers in osteoarthritis
Biological markers in osteoarthritis
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DOI：
10.1038/ncprheum0508
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发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Delmas, Pierre D.
中科院分区：
文献类型：
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作者：
Rousseau, Jean-Charles;Delmas, Pierre D.
骨关节炎（OA）是一种进行性疾病，其特征是关节软骨和软骨下骨的破坏以及滑膜的改变。OA的诊断一般基于临床和影像学变化，这些变化在疾病进展中出现较晚，监测疾病进展的敏感性较差。关节损伤的进展可能主要是由软骨退化和修复之间的不平衡引起的，因此测量这些过程的标志物似乎是一种在个体水平上改善疾病进展预测的有希望的方法。此外，遗传标记可能是有用的预测预后。缺乏完全有效的软骨保护药物限制了这些潜在标志物用于监测OA治疗效果的使用。然而，由于生物标志物对治疗反应的动态变化，它们可能比成像技术（如x线摄影和MRI）更快地提供相关信息，并有助于我们理解OA治疗临床疗效的机制。大多数已确定的与OA相关的基因编码信号转导蛋白，这为新的治疗方法提供了潜力。在这篇综述中，我们将使用最近提出的OA标记物的BIPED（即疾病负担、调查性、预后、干预效果和诊断）分类来描述给定标记物的潜在用途。
Osteoarthritis (OA) is a progressive disorder characterized by destruction of articular cartilage and subchondral bone, and by synovial changes. The diagnosis of OA is generally based on clinical and radiographic changes, which occur fairly late during disease progression and have poor sensitivity for monitoring disease progression. Progression of joint damage is likely to result primarily from an imbalance between cartilage degradation and repair, so measuring markers of these processes would seem a promising approach to improve the prediction of disease progression at the individual level. Moreover, genetic markers might be useful predictors of prognosis. The lack of fully effective, chondroprotective medications has limited the use of such potential markers to monitor the effect of treatment for OA. Nevertheless, owing to their dynamic changes in response to treatment, biological markers might provide relevant information more rapidly than imaging techniques (such as radiography and MRI) can, and should contribute to our understanding of mechanisms that underlie the clinical efficacy of OA treatments. Most of the identified genes involved in OA encode signal-transduction proteins, which provide the potential for novel therapeutic approaches. In this Review, we will use the recently proposed BIPED (i.e. burden of disease, investigative, prognostic, efficacy of intervention and diagnostic) classification of OA markers to describe the potential usage of a given marker.