Toll-like receptor initiated host defense against Toxoplasma gondii.
Toll-like receptor initiated host defense against Toxoplasma gondii.
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DOI：
10.1155/2010/737125
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发表时间：
2010
影响因子：
--
通讯作者：
Denkers EY
中科院分区：
文献类型：
--
作者：
Denkers EY
Toxoplasma gondii is an intracellular pathogen notable for its ability to establish a stable host-parasite relationship amongst a wide range of host species and in a large percentage of the human population. Toll-like receptor signaling through MyD88 is a critical pathway in initiating defense against this opportunistic protozoan and may also be a mediator of pathology during immune dysfunction. Other MyD88 independent signaling pathways are also involved in the host-parasite interaction. These responses can be triggered by the parasite itself, but interactions with the intestinal microbiota add additional complexity during enteric infection.
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